Influence of tranexamic acid in postoperative bleeding of cardiac surgery with cardiopulmonary bypass

Abstract

GONÇALVES, FD ET AL -Influence of tranexamic acid in postoperative bleeding of cardiac surgery with cardiopulmonary bypassRev Bras Cir Cardiovasc 2002; 17(4): 331-338 Abstract Objective: To analyze the influence of tranexamic acid in postoperative bleeding of cardiac surgery with cardiopulmonary bypass.Method: 51 patients who underwent heart surgery with cardiopulmonary bypass were randomly divided in 2 groups: Group I -control, with 12 coronary artery disease patients and 14 valve disease patients. Results: Concerning the postoperative bleeding and transfusion required, there was a statistically significant reduction in its average in valve disease patients in Group II. In coronary disease patients there was only a slight tendency. There was no significant statistical difference as far as the thromboembolic or renal complications were concerned.Conclusion: In valve disease patients, there was a reduction in bleeding and the need of transfusions of red blood cells, both of which had statistical differences. In coronary disease patients there was only a reduced tendency. The use of tranexamic acid was not related to further thromboembolic complications or renal insufficiency in the assessed groups.Descriptors: Tranexamic acid, therapeutic use. Cardiac surgical procedures. Fibrinogen