Influence of transurethral catheters on urine pressure-flow relationships in males: A computational fluid-dynamics study

Mascolini, Maria Vittoria; Fontanella, Chiara Giulia; Berardo, Alice; Carniel, Emanuele Luigi

doi:10.1016/j.cmpb.2023.107594

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…Currently, this case study sets the basis for the investigation approach for future developments which would require the extension of the numerosity of the population samples to improve the experimental data reliability. Characterization of the essential mechanical properties of the LUT may represent a key aspect for the development of effective in silico models to extend the experimental results to high-level scenarios providing additional information on LUT dysfunctions and reliable diagnostic and/or therapeutic tools for the urological clinical and surgical context [26][27][28]. The study and validation process of innovative procedures and devices for the treatment of LUT pathologies, such as balloon catheters for dilating urethral strictures or artificial sphincters for restoring urinary continence condition [29][30][31][32][33], needs to be considered according to the mechanical behavior of the biological tissues and structures involved, as well as the development and suitability of phantoms mimicking the tissue performance for surgical planning and training [34] and the tissue engineering for surgical reconstruction of anatomical or functional defects [35,36].…”

Section: Discussionmentioning

confidence: 99%

Mechanical Characterization of the Male Lower Urinary Tract: Comparison among Soft Tissues from the Same Human Case Study

Berardo,

Mascolini,

Fontanella

et al. 2024

Applied Sciences

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Background: Nowadays, a challenging task concerns the biomechanical study of the human lower urinary tract (LUT) due to the variety of its tissues and the low availability of samples. Methods: This work attempted to further extend the knowledge through a comprehensive mechanical characterization of the male LUT by considering numerous tissues harvested from the same cadaver, including some never studied before. Samples of the bladder, urethra, prostate, Buck’s fascia and tunica albuginea related to corpora cavernosa were considered and distinguished according to testing direction, specimen conformation and anatomical region. Uniaxial tensile and indentation tests were performed and ad hoc protocols were developed. Results: The tissues showed a non-linear and viscoelastic response but different mechanical properties due to their specific functionality and microstructural configuration. Tunica albuginea longitudinally displayed the highest stiffness (12.77 MPa), while the prostate transversally had the lowest one (0.66 MPa). The minimum stress relaxation degree (65.74%) was reached by the tunica albuginea and the maximum (88.55%) by the bladder. The prostate elastic modulus was shown to vary according to the presence of pathological changes at the microstructure. Conclusions: This is the first experimental work that considers the mechanical evaluation of the LUT tissues in relation to the same subject, setting the basis for future developments by expanding the sample population and for the development of effective in silico models to improve the solutions for most LUT pathologies.

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Section: Discussionmentioning

confidence: 99%

Mechanical Characterization of the Male Lower Urinary Tract: Comparison among Soft Tissues from the Same Human Case Study

Berardo,

Mascolini,

Fontanella

et al. 2024

Applied Sciences

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“…The present paper included the computational modelling as it is increasingly used to investigate vast surgical scenarios and predict possible controversies. This allows comparisons among innovative techniques and technologies without performing premature clinical trials ( Riva et al, 2019 ; Salmaso et al, 2020 ; Steer et al, 2021 ; Hennicke et al, 2022 ; Mascolini et al, 2023 ; Toniolo et al, 2024 ) starting from an experimental campaign of related biological tissues ( Carniel et al, 2020 ; Pettenuzzo et al, 2023 ). By combining an experimental and computational approach ( Toniolo et al, 2022 ), the constitutive parameters can be obtained after choosing a suitable material model that can describe the main mechanical features and can be validated (intended to be able to accurately predict mechanical behaviour) by comparing the experimental evidence with the model results.…”

Section: Discussionmentioning

confidence: 99%

Mechanical characterization of porcine ureter for the evaluation of tissue-engineering applications

Casarin,

Toniolo,

Todesco

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: Clinics increasingly require readily deployable tubular substitutes to restore the functionality of structures like ureters and blood vessels. Despite extensive exploration of various materials, both synthetic and biological, the optimal solution remains elusive. Drawing on abundant literature experiences, there is a pressing demand for a substitute that not only emulates native tissue by providing requisite signals and growth factors but also exhibits appropriate mechanical resilience and behaviour.Methods: This study aims to assess the potential of porcine ureters by characterizing their biomechanical properties in their native configuration through ring and membrane flexion tests. In order to assess the tissue morphology before and after mechanical tests and the eventual alteration of tissue microstructure that would be inserted in material constitutive description, histological staining was performed on samples. Corresponding computational analyses were performed to mimic the experimental campaign to identify the constitutive material parameters.Results: The absence of any damages to muscle and collagen fibres, which only compacted after mechanical tests, was demonstrated. The experimental tests (ring and membrane flexion tests) showed non-linearity for material and geometry and the viscoelastic behaviour of the native porcine ureter. Computational models were descriptive of the mechanical behaviour ureteral tissue, and the material model feasible.Discussion: This analysis will be useful for future comparison with decellularized tissue for the evaluation of the aggression of cell removal and its effect on microstructure. The computational model could lay the basis for a reliable tool for the prediction of solicitation in the case of tubular substitutions in subsequent simulations.

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“…Zhang et al 10 ran a 2D CFD simulation using ultrasound images. There are several other studies that have used idealized bladder and urethra geometries instead of medical images 20,21 . To the best of our knowledge, this is the first time volumetric dynamic MRI has been used to run a wallmotion driven CFD simulation of bladder voiding.…”

Section: Discussionmentioning

confidence: 99%

Computational Fluid Dynamics Of Bladder Voiding Using 3D Dynamic MRI: A Pilot Study

Shahid,

Gonzalez-Pereira,

Johnson

et al. 2023

Preprint

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Over the last couple of decades, image-based computational fluid dynamics (CFD) has revolutionized cardiovascular research by uncovering hidden features of wall strain, impact of vortices, and its use in treatment planning, as examples, that were simply not evident in the gold-standard catheterization studies done previously. In the work presented here, we have applied magnetic resonance imaging (MRI)-based CFD to study bladder voiding and to demonstrate the feasibility and potential of this approach. We used 3D dynamic MRI to image the bladder and urethra during voiding. A surface mesh processing tool was developed to process the bladder wall prior to executing a wall-motion driven CFD simulation of the bladder and urethra. The obtained flow rate and pressure were used to calculate urodynamic nomograms which are currently used in the clinincal setting to assess bladder voiding dysfunction. These nomograms concluded that our healthy volunteer has an unobstructed bladder and normal contractility. We calculated the work done to void the bladder and propose this as an additional quantitative metric to comprehensively assess bladder function. Further, we discuss the areas that would improve this relatively new methodology of image-based CFD in urodynamics.

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Influence of transurethral catheters on urine pressure-flow relationships in males: A computational fluid-dynamics study

Cited by 9 publications

References 25 publications

Mechanical Characterization of the Male Lower Urinary Tract: Comparison among Soft Tissues from the Same Human Case Study

Mechanical Characterization of the Male Lower Urinary Tract: Comparison among Soft Tissues from the Same Human Case Study

Mechanical characterization of porcine ureter for the evaluation of tissue-engineering applications

Computational Fluid Dynamics Of Bladder Voiding Using 3D Dynamic MRI: A Pilot Study

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