The
giant magnetoresistance (GMR) effect has seen flourishing development
from theory to application in the last three decades since its discovery
in 1988. Nowadays, commercial devices based on the GMR effect, such
as hard-disk drives, biosensors, magnetic field sensors, microelectromechanical
systems (MEMS), etc., are available in the market, by virtue of the
advances in state-of-the-art thin-film deposition and micro- and nanofabrication
techniques. Different types of GMR biosensor arrays with superior
sensitivity and robustness are available at a lower cost for a wide
variety of biomedical applications. In this paper, we review the recent
advances in GMR-based biomedical applications including disease diagnosis,
genotyping, food and drug regulation, brain and cardiac mapping, etc.
The GMR magnetic multilayer structure, spin valve, and magnetic granular
structure, as well as fundamental theories of the GMR effect, are
introduced at first. The emerging topic of flexible GMR for wearable
biosensing is also included. Different GMR pattern designs, sensor
surface functionalization, bioassay strategies, and on-chip accessories
for improved GMR performances are reviewed. It is foreseen that combined
with the state-of-the-art complementary metal-oxide-semiconductor
(CMOS) electronics, GMR biosensors hold great promise in biomedicine,
particularly for point-of-care (POC) disease diagnosis and wearable
devices for real-time health monitoring.