Influence of treatment on morphological features of mucosal inflammation

Mucosal healing with methotrexate in Crohn’s disease: a prospective comparative study with azathioprine and infliximab

“…18 Moreover, the correlation between clinical and endoscopic findings with histology is a matter of debate. 32 In the present study that enrolled patients in clinical remission, endoscopic and histologic activities were not correlated. Furthermore, there is no validated and standardised microscopic scoring system for Crohn's disease.…”

“…Nevertheless, the evolution of the microscopic intestinal features has been poorly investigated and there is a lack of data regarding histological response to the main medications used in Crohn's disease. Some changes have been observed, mainly on signs of mucosal injury and the presence of neutrophils, 32 and in a small placebo-controlled study, significant histological improvement due to the disappearance of the inflammatory infiltrate was seen after a single infliximab infusion. 18 Moreover, the correlation between clinical and endoscopic findings with histology is a matter of debate.…”

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

“…The leukocytic infiltrate disappeared with only isolated clusters of CD11c ϩ and CD4 ϩ T cells remaining in the LP. Interestingly, similar normalization of the mucosa with remaining leukocytic clusters has been observed in IBD patients after treatment with immunosuppressive or anti-inflammatory drugs (12). Additional experiments are required to determine whether T R cell therapy will also be effective at resolving inflammation in nonlymphopenic hosts.…”

MR imaging in Crohn's disease: correlation of MR motility measurement with histopathology in the terminal ileum

“…14, 15 The grade of bowel wall inflammation was further classified as low or high degree according to the pathologist's description.…”