Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD)

Mueller, Dolores; Triebel, Sven; Rudakovski, Olga; Richling, Elke

doi:10.1016/j.foodchem.2013.01.101

Cited by 52 publications

(28 citation statements)

References 40 publications

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“…Betulinic acid (BA) is an active natural triterpenoid acid obtained not only from condiments and fruits, such as Rhus tripartium (Ucria) [1], Rosmarinus officinalis L [2], Dillenia indica [3], table olives [4], sour jube fruits [5], apple [6], seasonal fruits [7], but also from many traditional Chinese herbal medicines, such as Rosae Laevigata Michx [8], Paeonia spp [9]. In recent years, BA has attracted increasing attention due to its antitumor, antioxidant, anti-inflammatory, Article Related Abbreviations: BA, Betulinic acid; CDS, calibration delivery system; CMC-Na, carboxyl methyl cellulose; DBS, dynamic background subtraction; HRMS, high-resolution mass spectrometry; IDA, information dependent acquisition; MDF, mass defect filter; MMDF, multiple mass defilter; NLF, neutral loss filter; PIF, product ion filter; TCM, traditional Chinese medicine; XIC, extract ion chromatogram anti-HIV, antiatherogenic, antihyperlipidemic, antidiabetic, and hepatoprotective activities [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time‐of‐flight mass spectrometry

Zhang

Jin

Jiang

et al. 2018

J of Separation Science

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Betulinic acid is a triterpenoid organic acid with remarkable antitumor properties and is naturally present in many fruits, condiments and traditional Chinese medicines. Currently, a strategy was developed for the identification of metabolites following the in vivo and in vitro biotransformation of Betulinic acid with rat intestinal bacteria utilizing ultra high performance liquid chromatography with time‐of‐flight mass spectrometry with polymeric solid‐phase extraction. As a result, 46 metabolites were structurally characterized. The results demonstrated that Betulinic acid is universally metabolized in vivo and in vitro, and Betulinic acid could undergo general metabolic reactions, including oxidation, methylation, desaturation, loss of O and loss of CH2. Additionally, the main metabolic pathways in vivo and in vitro were determined by calculating the relative content of each metabolite. This is the first study of Betulinic acid metabolism in vivo, whose results provide novel and useful data for better understanding of the safety and efficacy of Betulinic acid.

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Section: Introductionmentioning

confidence: 99%

Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time‐of‐flight mass spectrometry

Zhang

Jin

Jiang

et al. 2018

J of Separation Science

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“…Recently, an increasing number of researchers have become interested in identifying anti-inflammatory factors from fruits, leading to the discovery of a lot of novel anti-inflammatory ingredients (Hasnaoui, Wathelet, & Jimenez-Araujo, 2014;Mueller, Triebel, Rudakovski, & Richling, 2013).…”

Section: Introductionmentioning

confidence: 99%

Flavonoid glycosides from Rubus chingii Hu fruits display anti-inflammatory activity through suppressing MAPKs activation in macrophages

Zhang

Wang

Yang

et al. 2015

Journal of Functional Foods

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“…[49] Several mechanisms have been proposed to explain the antiinflammatory action of phytoconstituents: (i) Antioxidative and free radical scavenging activities, (ii) modulation of cellular activities of inflammation related to cells, (iii) modulation of pro-inflammatory enzyme activities, and (iv) modulation of pro-inflammatory gene expression. [49][50][51][52][53][54][55][56] Phytochemical screening of the RCRE revealed the presence of carbohydrate, glycosides, saponins, flavonoids, alkaloids, tannins, and phenolic compounds. These phytoconstituents have been found to be effective in various models of IBD and may explain the antioxidant and anti-inflammatory activity of RCRE.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Saiyed¹

2017

IJGP

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Introduction: Ulcerative colitis (UC) is an idiopathic, autoimmune, and inflammatory disorder which affects the lining of the colon and the rectum. It involves inflammatory mediators such as cytokines, nitrogen and oxygen-derived free radicals exerting oxidative stress, deranged colonic milieu, and increase in intestinal permeability. Ricinus communis roots are used traditionally in diseases of liver and rectum, in gastropathy such as constipation, inflammation, fever, colic and in colon cancer. Several reports exhibiting analgesic, antibacterial, anti-inflammatory, and antioxidant activity of R. communis root extract (RCRE) are available. Hence, this study was undertaken with the objective to evaluate the effectiveness of RCRE in dextran sodium sulfate (DSS) induced UC in rats. Materials and Methods: A total of 30 Sprague-Dawley rats were divided into five groups (n = 6). 5-Aminosalicylic acid was used as a standard drug, and RCRE was administered at a dose of 250 mg/kg and 500 mg/kg p.o. for 14 days. UC was induced by replacing drinking water with 4% DSS solution for the past 7 days. Results: Severity of colitis induced was assessed by observing macroscopic and microscopic characteristics and changes in the level of oxidative stress parameters. All parameters were altered in model control rats, while pretreatment with RCRE preserved normal colonic architecture, improved macroscopic and microscopic scores and altered oxidative stress biomarkers in the colon. Conclusion: Results showed the good effectiveness of RCRE against DSS-induced UC possibly by its anti-inflammatory and antioxidant activity.

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Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD)

Cited by 52 publications

References 40 publications

Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time‐of‐flight mass spectrometry

Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time‐of‐flight mass spectrometry

Flavonoid glycosides from Rubus chingii Hu fruits display anti-inflammatory activity through suppressing MAPKs activation in macrophages

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