Influence of TRPV3 mutation on hair growth cycle in mice

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

“…For example, the constitutively active, gain-of-function trpv3 gene mutation (TRPV3 G573S ) is associated with a hairless phenotype both in DS-Nh mice and WBN/Kob-Ht rats (Asakawa et al, 2006;Xiao et al, 2008). In these animals, histologic analysis revealed impaired hair follicle morphogenesis and hair cycling (Imura et al, 2007). In rodents, TRPV3 is thought to form a signalplex with TNFa and the EGFR that regulates hair morphogenesis.…”

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

“…ATP interacts with the channel's N-terminal ankyrin repeats to regulate this sensitization (Phelps et al, 2010). Elevated TRPV3 activity can dramatically influence skin integrity; rodents with constitutively active TRPV3 channels have an increased susceptibility to dermatitis and skin lesions (Asakawa et al, 2006;Imura et al, 2007).…”

The Ca2+-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases

“…DS-Nh mice (Gly573 mutated to Ser) and WBN/Kob-Ht rats (Gly573 mutated to Cys) are spontaneous hairless mutant strains in rodents that develop AD-like dermatitis under normal conditions, but not under specific pathogen-free conditions (Asakawa et al, 2006;Yoshioka et al, 2009). In rodents, spontaneous dermatitis conditions share very similar characteristics that include the following (Asakawa et al, 2006;Imura et al, 2007): 1) Staphylococcus aureus can be isolated from skin lesions, 2) levels of serum interleukin-4 and IgE are increased significantly, 3) CD4-bearing T cells and whole mast cells are increased significantly, and 4) hyperkeratosis is observed in skin lesions with dermatitis. In DS-Nh mice expressing an overactive TRPV3 mutant, expression of thymic stromal lymphopoietin, a pruritogen, is increased in keratinocytes (Wilson et al, 2013;Yamamoto-Kasai et al, 2013), indicating that TRPV3 is a dendritic cell modulator that plays a critical role in the development of allergic dermatitis.…”