Influence of tumor necrosis factor alpha gene promoter polymorphisms and its serum level on migraine susceptibility in Egyptian patients

Fawzi, Mohamed; El‐Shal, Amal S.; Rashad, Nearmeen M.; Fathy, Hala A.

doi:10.1016/j.jns.2014.11.009

Cited by 11 publications

(9 citation statements)

References 38 publications

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“…The comprehensive literature search in the available databases using PRISMA guidelines retrieved a total of 176 publications of which 10 studies were selected for meta-analysis. All the selected studies [11,[22][23][24][25][26][27][28][29][30] were assessed for quality using on HWE and Newcastle Ottawa Scale. The main characteristics such as study name with year, ethnic origin, country, DNA isolation source, Mg diagnostic criteria, total no of study participants (Migraineurs and healthy controls), NOS Score, genotyping methods, allele and genotypic frequencies, HWE, and chi-square are summarized in Tables 4 (Ref.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…The main characteristics such as study name with year, ethnic origin, country, DNA isolation source, Mg diagnostic criteria, total no of study participants (Migraineurs and healthy controls), NOS Score, genotyping methods, allele and genotypic frequencies, HWE, and chi-square are summarized in Tables 4 (Ref. [11,[22][23][24][25][26][27][28][29][30]), 5 (Ref. [11,[22][23][24][25][26][27][28][29][30]).…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…Among several SNPs identified in the TNFα gene (rs1800629; g.-308 G>A) has been found to be associated with MA and MO. This SNP has been observed with the increase of TNFα gene expression thereby leading to higher levels of cytokine, further contributing to Mg patho-genesis [11]. In this study, the rs1800629 polymorphism was selected, since no case-control studies were published from Indian population of Asian ethnicity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic predisposition of TNFα gene polymorphism in South-Indian Migraineurs and meta-analysis

Kesavan,

Satheesh,

Husain

et al. 2021

Front. Biosci. (Elite Ed)

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Introduction 3. Methodology 3.1 Stage 1: case-control study 3.2 Meta-analysis 4. Results 4.1 Geographical attribute 4.2 Genotypic frequencies of rs1800629 SNP among South-Indian Migraineurs 4.3 Literature search and study characteristics 4.4 Meta-analysis of rs1800629 polymorphism with Mg risk 5. Discussion 6. Conclusions 7. Author contributions 8. Ethics approval and consent to participate 9. Acknowledgment 10. Funding 11. Conflict of interest 12. References

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Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic predisposition of TNFα gene polymorphism in South-Indian Migraineurs and meta-analysis

Kesavan,

Satheesh,

Husain

et al. 2021

Front. Biosci. (Elite Ed)

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“…Those results showed that COX-2 was involve in the process of acute migraine headache attack and might promote the occurrence of headache attack. We speculate that the specific mechanism might be as follows: in the migraine attack period the expression levels of some specific proinflammatory factors, such as tumor necrosis factor and NF-κB are elevated [14,15], these proinflammatory factors can upregulate the expression of COX-2 [16,17], and the expression of prostaglandin will then be raised by the irritation of COX-2 [18]. High levels of prostaglandin can directly affect the cerebral vascular and platelet function, and promote the occurrence of a headache attack [19].…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Cyclooxygenase-2 (COX-2) and Visfatin During Different Stages and Different Subtypes of Migraine Headaches

Zhu

et al. 2017

Med Sci Monit

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BackgroundThe aim of this study was to determine the plasma levels of cyclooxygenase-2 (COX-2) and visfatin in different stages and different subtypes of migraine headaches compared to a control group to elucidate the pathological mechanisms involved.Material/MethodsWe recruited a case-control cohort of 182 adult migraine patients and 80 age-matched and gender-matched healthy controls. The migraine patients were divided into two groups: the headache-attack-period group (Group A, n=77) and the headache-free-period group (Group B, n=105). The two groups were further divided into subgroups according to whether they had aura symptoms. Solid phase double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma levels of COX-2 and visfatin. Statistical analysis was performed using SPSS 17.0.ResultsThe plasma levels of COX-2 and visfatin in the headache-attack-period group were significantly higher than in the headache-free-period group and the control group; there were no significant differences between the headache-free group and the control group. There were no significant differences in plasma levels of COX-2 and visfatin between the subgroups: headache-attack-period with aura subgroup and the headache-attack-period without aura sub group.ConclusionsCOX-2 and visfatin participated in the pathogenesis of migraine headaches. The presence of aura had no effect on the serum levels of COX-2 and visfatin.

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“…However, the pathogenesis of migraine is not clear enough. Therefore, recent studies have devoted the genetic susceptibility research which may also be a neurobiological factor in the etiology of this disorder (12)(13)(14). Familial hemiplegic migraine (FHM), an autosomal dominant migraine with special aura, has been identified mutations in three causal genes (15).…”

Section: Introductionmentioning

confidence: 99%

Migraine in the era of precision medicine

Zhang

Dong

Yu³

2016

Ann. Transl. Med.

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Migraine is a common neurovascular disorder in the neurologic clinics whose mechanisms have been explored for several years. The aura has been considered to be attributed to cortical spreading depression (CSD) and dysfunction of the trigeminovascular system is the key factor that has been considered in the pathogenesis of migraine pain. Moreover, three genes (CACNA1A, ATP1A2, and SCN1A) have come from studies performed in individuals with familial hemiplegic migraine (FHM), a monogenic form of migraine with aura. Therapies targeting on the neuropeptids and genes may be helpful in the precision medicine of migraineurs. 5-hydroxytryptamine (5-HT) receptor agonists and calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated efficacy in the acute specific treatment of migraine attacks. Therefore, ongoing and future efforts to find new vulnerabilities of migraine, unravel the complexity of drug therapy, and perform biomarker-driven clinical trials are necessary to improve outcomes for patients with migraine.

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Influence of tumor necrosis factor alpha gene promoter polymorphisms and its serum level on migraine susceptibility in Egyptian patients

Cited by 11 publications

References 38 publications

Genetic predisposition of TNFα gene polymorphism in South-Indian Migraineurs and meta-analysis

Genetic predisposition of TNFα gene polymorphism in South-Indian Migraineurs and meta-analysis

Plasma Levels of Cyclooxygenase-2 (COX-2) and Visfatin During Different Stages and Different Subtypes of Migraine Headaches

Migraine in the era of precision medicine

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