Abstract. -The superconducting current-phase relation (CPR) of Nb/Au/(001)YBa2Cu3Ox heterojunctions prepared on epitaxial c-axis oriented YBa2Cu3Ox thin films has been measured in a single-junction interferometer. For the first time, the second harmonic of the CPR of such junctions has been observed. The appearance of the second harmonic and the relative sign of the first and second harmonics of the CPR can be explained assuming, that the macroscopic pairing symmetry of our YBa2Cu3Ox thin films is of the d + s type.Introduction. It is now well established that the dominant component of the superconducting order parameter in the cuprates has d-wave symmetry (see [1] and references therein). Moreover, it has become clear that in orthorhombic materials such as YBa 2 Cu 3 O x (YBCO), a finite component with s-wave symmetry is admixed to the dominant d-wave order parameter. The early in-plane phase sensitive experiments imply that the d-wave component remains coherent through the whole sample [1], while an elegant c-axis tunneling experiment shows directly that the s-wave order parameter component does change sign across the twin boundary [2].The above picture of the YBCO pairing state is challenged by the experimental observation of a finite c-axis Josephson current between heavily twinned YBCO and a Pb counterelectrode [3]. Namely, the contribution of the s-wave part of the YBCO order parameter to