Influence of type 2 diabetes microangiopathy on bone mineral density and bone metabolism: A meta-analysis

Zhao, Jinlong; Liang, Guihong; Luo, Miaohui; Yang, Wei; Xu, Nanjun; Luo, Minghui; Pan, Jianke; Li, Jun; Zeng, Lingfeng

doi:10.1016/j.heliyon.2022.e11001

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…For example, a case-control study conducted in China found that 35.77% of T2D patients had OP [34]. A meta-analysis examining the relationship between T2D and BMD also revealed that individuals with T2D have lower BMD in the lumbar spine and femoral neck and are at an increased risk of developing OP or fractures [35]. A 5-year cohort study in Italy further demonstrated that T2D is a signi cant risk factor for developing OP [36].…”

Section: Instrumental Strengthmentioning

confidence: 99%

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Genetically predicted type 2 diabetes may be a protective factor for bone mineral density：A Mendelian randomization study

Chen

Xiong

et al. 2023

Preprint

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Purpose: The aim of this study was to investigate the causal association between T2D and BMD using MR analysis. Methods: We obtained genetic data for T2D and BMD from previously published genome-wide association studies (GWAS). We selected single nucleotide polymorphisms (SNPs) with significant genome-wide differences(p<5×10-8) and independent (r2 < 0.001), and further analysed SNPs with F ≥ 10. To assess causality, we used inverse variance weighting (IVW) and reported results as odds ratios (ORs). We also tested for heterogeneity using Cochran's Q, tested for polymorphism using the MR-Egger intercept, and performed sensitivity analyses to ensure the robustness of our results. Results: The results showed that T2D was significantly associated with FN-BMD(β=0.049, 95%CI 0.021~0.077, p=0.001),LS-BMD(β=0.05, 95%CI 0.015~0.085,p=4.707*10-3), eBMD (β=0.028, 95%CI 0.01~0.045,p=0.002), TB-BMD(β=0.040,95%CI 0.015~0.064,p =0.002),TB-BMD(age over 60)(β=0.051,95%CI 0.016~0.086,p = 0.004),TB-BMD (age 45-60) (β=0.05,95%CI 0.014~0.087,p=0.007). Conclusion: In summary, our study suggests that T2D may act as a protective factor for BMD, we do not have sufficient evidence to support a causal effect of T2D on BMD at a genetically predicted level. More cases need to be included for analysis.

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Section: Instrumental Strengthmentioning

confidence: 99%

“…Clinical observational studies have found that patients with T2D have a higher risk of OP or osteoporotic fractures [5,6]. However, in clinical practice, T2D and OP are both common chronic diseases of the middleaged and elderly, and most patients have long disease courses with an unknown sequence.…”

Section: Introductionmentioning

confidence: 99%

Genetically predicted type 2 diabetes may be a protective factor for bone mineral density：A Mendelian randomization study

Chen

Xiong

et al. 2023

Preprint

View full text Add to dashboard Cite

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Diabetes and the Microvasculature of the Bone and Marrow

Le,

Salas Sanchez,

Nashawi

et al. 2024

Curr Osteoporos Rep

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Type 2 diabetes and bone mineral density: A meta-analysis and systematic review

Li,

Sun,

Chen

et al. 2024

Medicine

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Background: Type 2 diabetes (T2D), a widespread chronic metabolic disorder, presents frequently in clinical settings. The relationship between T2D and bone mineral density (BMD) has been subject to ongoing investigation, yielding inconclusive results. Methods: A systematic literature search was conducted across several databases, including CNKI, VIP, CBM, Wanfang, PubMed, Cochrane Library, and Embase, targeting observational studies that explored the impact of microangiopathy associated with T2D on BMD or bone metabolism. The search spanned from the inception of each database to July 1, 2023. The Newcastle–Ottawa Scale was employed for quality assessment, and RevMan 5.3 software was utilized for data analysis. Stata 14.0 was used for the quantitative evaluation of publication bias regarding outcome measures. Results: The inclusion criteria were met by 30 observational studies, comprising 6470 participants—3121 with diabetes and 3349 without. The meta-analysis revealed no significant difference in overall BMD between the nondiabetic and T2D groups (mean difference [MD] = −0.07, 95% confidence interval [CI] [−0.17, 0.03], Z = 1.45, P = .15). However, BMD at the lumbar vertebrae was significantly higher in nondiabetic individuals compared with those with T2D (MD = −0.14, 95% CI [−0.22, −0.06], Z = 3.32, P = 0.0009), as was the case with femoral neck BMD (MD = −0.11, 95% CI [−0.18, −0.04], Z = 3.08, P = .002). A difference in femoral neck BMD between nondiabetics and individuals with T2D approached but did not reach statistical significance (MD = −0.14, 95% CI [−0.27, 0.00], Z = 1.94, P = .05). An inverted funnel plot analysis suggested possible publication bias, as evidenced by an asymmetrical distribution of studies around the axis of symmetry, with overlap observed in several cases. Conclusion: The findings indicate a significant association between T2D and reduced BMD at critical sites such as the lumbar vertebrae and femoral neck, highlighting an increased risk of osteoporosis or osteoporotic fractures in these regions.

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Influence of type 2 diabetes microangiopathy on bone mineral density and bone metabolism: A meta-analysis

Cited by 5 publications

References 35 publications

Genetically predicted type 2 diabetes may be a protective factor for bone mineral density：A Mendelian randomization study

Genetically predicted type 2 diabetes may be a protective factor for bone mineral density：A Mendelian randomization study

Diabetes and the Microvasculature of the Bone and Marrow

Type 2 diabetes and bone mineral density: A meta-analysis and systematic review

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