Influence of urban/rural and coastal/inland environment on the prevalence, phenotype, and clinical course of inflammatory bowel disease patients from northwest of Spain

Carpio, Daniel; Acosta, Manuel Barreiro‐de; Echarri, Ana; Pereira, Santos; Castro, Javier; Ferreiro, Rocío; Lorenzo, Aurelio

doi:10.1097/meg.0000000000000395

Cited by 10 publications

(8 citation statements)

References 71 publications

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“…The overall prevalence of CD-related anal fistulas was calculated as the mean prevalence of anal fistulas in the Crohn's population, obtained from population-based, cross-sectional studies, multiplied by the weighted mean prevalence of CD/10,000 population in Europe, obtained from studies published over the last 10 years (2008-2017; Supplementary Material File 3) [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. The weighted mean prevalence of Crohn's disease was calculated on the basis of the 2017 mid-year populations [32].…”

Section: Literature Reviewmentioning

confidence: 99%

Prevalence of Anal Fistulas in Europe: Systematic Literature Reviews and Population-Based Database Analysis

Garcı́a-Olmo

Assche

Tagarro³

et al. 2019

Adv Ther

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Introduction: Despite the fact that perianal fistulas are associated with significant morbidity and impaired quality of life, their prevalence in Europe is unknown. The aim of this study was to estimate the prevalence of perianal fistulas in Europe, overall and according to etiology. Methods: Two independent literature reviews were performed using different search strategies to maximize the identification of potentially relevant studies. Data from relevant articles were used to estimate the prevalence of perianal fistulas in Europe. The robustness of the estimate was evaluated using data from a large population-based database from the UK. Results: A total of 26 studies provided epidemiological data on perianal fistulas, of which 16 provided suitable data to estimate the prevalence. Estimations using these data yielded a total prevalence of 1.69 per 10,000 population. Cryptoglandular infection and Crohn's disease (CD) were the predominant etiologies, with prevalence rates at 0.86 and 0.76 per 10,000 population, respectively. Comparison of prevalence data from the UK population-based database with the European population resulted Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.9948788.

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Section: Literature Reviewmentioning

confidence: 99%

Prevalence of Anal Fistulas in Europe: Systematic Literature Reviews and Population-Based Database Analysis

Garcı́a-Olmo

Assche

Tagarro³

et al. 2019

Adv Ther

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“…24,25 The place of residence may also affect the phenotype and clinical course of the disease. 26 Family history of the disease, which is greater among pediatric-onset UC and is with more disease severity, was detected in 25.6% of the patients similar to other parts of Asia and more than the results reported by Moller and colleagues in Europe 27,28 Bloody diarrhea was the most common presentations like another study at the disease onset. 29 Most of the patients had left colon involvement so higher frequency of abdominal pain could be due to the presence of concomitant irritable bowel syndrome.…”

Section: Discussionmentioning

confidence: 74%

Epidemiologic Characteristics of Patients with Inflammatory Bowel Disease in Kermanshah, Iran

Zobeiri

Bashiri

Askari

et al. 2017

Middle East J Dig Dis

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BACKGROUND This study was done to define some epidemiological aspects of inflammatory bowel disease (IBD), and to describe its characteristics in west of Iran. METHODS In this descriptive study all patient with the diagnosis of IBD who were visited in universityaffiliated medical centers, between 2014 and 2015 were recruited. Their demographic characteristics, disease-related manifestations, complications, disease course and their chief complaints were analyzed. RESULTS Of 156 referred individuals, 153 patients had ulcerative colitis (UC) and 3 patients had Crohn’s diseases (CD). The mean age of the patients at diagnosis was 35.69±12.35 (range: 17-80) years with the most common age group of 25-35 years and slight female predominance (51.9%). More urban patients were registered (90.4%) and 57% had high school or upper education. Positive family history of the disease was in 25.6% and 66.6% had four or more family members. Furthermore, 51.9% had left sided colitis and 40.4% had pancolitis with bloody diarrhea (79.5%) and abdominal pain (68.6%) as the most common manifestations. 36.5% had other autoimmune diseases. Multiple flare was seen in 47.4%, most commonly due to drug discontinuation (26.28%). Hospital admission was reported in 34.6%. History of contraceptive pill use was in 38.8% of the female patients. CONCLUSION The demographic and clinical manifestations of IBD are usually the same as other developing countries; however, the rarity of CD is eminent. Although the accurate epidemiological characteristic of IBD in Iran is still obscure, it is not a rare disease as previously thought and it seems that gradual reception of a western lifestyle may be linked to the ongoing rise in IBD.

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“…[3][4][5][6][7] The Spanish incidence of IBD seems to have increased in recent years, similarly to other countries, 8 9 and ranges between 8 and 11 cases per 100 000 inhabitants per year. [10][11][12] IBD has been frequently associated with comorbidities that, although not having a direct relationship with bowel inflammation, can modify the course and management outcomes of the disease. 13 The prevalence of comorbidities in patients with IBD ranges between 30% and 70%.…”

Section: What Are the New Findings?mentioning

confidence: 99%

Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease: the VERNE study

Marín-Jiménez

Bastida

Forés

et al. 2020

BMJ Open Gastroenterol

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ObjectiveTo evaluate the impact of comorbidities and extraintestinal manifestations of inflammatory bowel disease on the response of patients with inflammatory bowel disease to antitumour necrosis factor alpha (anti-TNFα) therapy.DesignData from 310 patients (194 with Crohn’s disease and 116 with ulcerative colitis) treated consecutively with the first anti-TNFα in 24 Spanish hospitals were retrospectively analysed. Univariate and multivariate logistic regression analyses were performed to assess the associations between inflammatory bowel disease comorbidities and extraintestinal manifestations with anti-TNFα treatment outcomes. Key clinical features, such as type of inflammatory bowel disease and concomitant treatments, were included as fixed factors in the model.ResultsMultivariate logistic regression analyses (OR, 95% CI) showed that chronic obstructive pulmonary disease (2.67, 1.33 to 5.35) and hepato-pancreato-biliary diseases (1.87, 1.48 to 2.36) were significantly associated with primary non-response to anti-TNFα, as was the use of corticosteroids and the type of inflammatory bowel disease (ulcerative colitis vs Crohn’s disease). It was also found that myocardial infarction (3.30, 1.48 to 7.35) and skin disease (2.73, 1.42 to 5.25) were significantly associated with loss of response, along with the use of corticosteroids and the type of inflammatory bowel disease (ulcerative colitis vs Crohn’s disease).ConclusionsOur results suggest that the presence of some comorbidities in patients with inflammatory bowel disease, such as chronic obstructive pulmonary disease and myocardial infarction, and of certain extraintestinal manifestations of inflammatory bowel disease, such as hepato-pancreato-biliary conditions and skin diseases, appear to be related to failure to anti-TNFα treatment. Therefore, their presence should be considered when choosing a treatment.Trial registration numberNCT02861118.

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Influence of urban/rural and coastal/inland environment on the prevalence, phenotype, and clinical course of inflammatory bowel disease patients from northwest of Spain

Cited by 10 publications

References 71 publications

Prevalence of Anal Fistulas in Europe: Systematic Literature Reviews and Population-Based Database Analysis

Prevalence of Anal Fistulas in Europe: Systematic Literature Reviews and Population-Based Database Analysis

Epidemiologic Characteristics of Patients with Inflammatory Bowel Disease in Kermanshah, Iran

Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease: the VERNE study

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