Influence of Urethane on Susceptibility to Leukæmia Induction by Graffi Virus in Adult Mice

Chieco‐Bianchi, Luigi; Fiore-Donati, L; Benedictis, G. De; Tridente, Giuseppe

doi:10.1038/199292a0

Cited by 21 publications

(6 citation statements)

References 3 publications

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“…In addition to the carcinogenic action on lung tissue, known since the early work of Nettleship and Henshaw (1943), urethane has recently been found to have an initiating action in skin carcinogenesis (Salaman and Roe, 1953;Graffi et al, 1953) as well as the property of enhancing leukaemogenesis by methylcholanthrene, oestrogenic hormones, X-rays, or viruses (Kawamoto et at., 1958;Berenblum andTrainin, 1960, 1961;Chieco-Bianchi et al, 1963). Moreover, the experimentation on newborn or infant mice (Pietra, Rappaport and Shubik, 1961;Fiore-Donati et al, 1961;Liebelt, Yoshida and Gray, 1961;Doell and Carnes, 1962; Klein, 1962) offered an opportunity to establish a further broadening of the oncogenic properties of urethane, which is now considered as a multipotential carcinogen not only for mice (Tannenbaum and Silverstone, 1958) but also for hamsters (Toth, Tomatis and Shubik, 1961) and rats (Tannenbaum et al, 1962).…”

mentioning

confidence: 99%

Influence of Age on Susceptibility to Liver Carcinogenesis and Skin Initiating Action by Urethane in Swiss Mice

Chieco‐Bianchi¹,

Benedictis²,

Tridente³

et al. 1963

Br J Cancer

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mentioning

confidence: 99%

Influence of Age on Susceptibility to Liver Carcinogenesis and Skin Initiating Action by Urethane in Swiss Mice

Chieco‐Bianchi¹,

Benedictis²,

Tridente³

et al. 1963

Br J Cancer

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“…However, ethyl carbamate did not affect or only slightly affected cell-mediated immunity (DiMarco et al, 1972;Lapp6 and Steinmuller, 1970;Luster et al, 1982;Parmiani, 1970). Ethyl carbamate did not affect the resistance of mice to encephalomyocarditis virus infection, but increased the incidence of induced leukemia (Chieco-Bianchi et al, 1963). Administration of ethyl carbamate (200-400 mg/kg) for 14 days to mice reduced splenic and thymic weight and increased splenic myelopoiesis.…”

Section: Ethyl and Methyl Carbamatementioning

confidence: 99%

Immunotoxicity of Pesticides

Rodgers

2001

Handbook of Pesticide Toxicology

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“…Long range studies have also shown urethan to be carcinogenic (TANNENBAUM and SILVERSTONE, 1958;HESTON et al, 1960;TOTH et al, 1961;DE BENEDICTIS et al, 1962;TANNENBAUM et al, 1962;DELLA PORTA et al, 1963) and leukemogenic (FIORE-DONATI et al, 1961 ;VESSELINOVITCH and MIHAILOVITCH, 1966). In addition, it increases the susceptibility to leukemia of mice inoculated previously with Graffi virus (CHIECO-BIANCHI et al, 1963) and it depresses interferon production (DE MAEYER-GUIGNARD and DE MAEYER, 1967).In attempts to-induce leukemia in cattle, urethan has been given to uninoculated newborn calves (HATZIOLOS, 1970) and to newborn calves previously inoculated with extracts derived from bovine lymphosarcoma (BLS) masses (HATZIOLOS, 1968(HATZIOLOS, , 1971(HATZIOLOS, a, 1971 or murine lymphosarcoma (MLS) material (HATZIOLOS, 1968, 1971 a, 1972). The results from these studies were promising.To increase knowledge concerning the pharmacodynamics of urethan in adult cattle, high but sublethal doses were given parenterally and this paper describes the clinical manifestations and the effects of urethan on the blood constituents of these animals.…”

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Effect of Sublethal Doses of Urethan in Adult Cattle

Hatziolos

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary High, but sublethal, doses (0.76–1.00 gm./kg. of body weight) of urethan were given to two young adult cattle to ascertain their clinical response and the possible lymphopoietic effects of this chemical. Small doses of urethan were tolerated quite well but a dose of 1.0 gm./kg. produced marked toxic effects on the CNS, including hypnosis, anesthesia, stupor and finally a semicomatose condition. In addition, the body temperature increased for a short period and then decreased by a fraction of 1 °C. The erythroid blood elements decreased immediately after urethan injection, while the leukocyte elements increased temporarily, followed by a decrease to below normal levels. The long range effect on the blood constituents was minimal. Although the circulating lymphoid cell (CLC) counts were higher in the urethan injected animals, the differences were not significant and no conclusion on the lymphopoietic role of urethan in adult cattle can be drawn. Zusammenfassung Wirkungen von subletalen Urethandosen bei erwachsenen Rindern An zwei junge erwachsene Rinder wurden hohe, jedoch subletale Urethandosen (0,76–1,00 g/kg Körpergewicht) verabfolgt und deren Wirkungen auf den klinischen Status und das lymphatische System untersucht. Kleine Urethandosen wurden gut vertragen, Dosen von 1,0 g/kg Körpergewicht verursachten hingegen ziemlich schwere toxische Erscheinungen von seiten des ZNS (Schlafsucht, Anästhesie, Stupor, leichtes Koma). Die Körpertemperatur stieg vorerst während kurzer Zeit an, fiel aber später um etwa 1 °C ab. Die erythrozytären Blutwerte sanken unmittelbar nach der Urethaninjektion, während die leukozytären Elemente vorerst zeitweise anstiegen und dann unter die Norm absanken. Die Langzeiteffekte auf das Blut waren gering. Die Lymphozyten des zirkulierenden Blutes waren zwar bei den mit Urethan behandelten Tiere höher. Die Differenzen waren jedoch nicht signifikant, so daß keine bindenden Schlußfolgerungen über den Einfluß von Urethan auf das lymphatische System gezogen werden können. Résumé Effets de doses sublétales d'uréthane chez des bovins adultes On a donné à deux jeunes bovins adultes de fortes doses, bien que sublétales, d'uréthane (0,76–1,00 g/kg de poids) et on a examiné les effets sur l'état clinique et le système lymphatique. De petites doses d'uréthane ont été bien supportées alors que des doses de 1,0 g/kg de poids ont par contre provoqué de graves symptômes d'intoxication du système nerveux central (somnolence, anesthésie, stupeur, léger coma). La température a tout d'abord augmenté pendant un bref laps de temps puis est retombé d'environ 1 °C. Les érythrocytes diminuèrent immédiatement après l'injection d'uréthane, alors que les leucocytes augmentèrent parfois au commencement pour redescendre en‐dessous de la norme. Les effets de longue durée sur le sang furent faibles. Les lymphocytes circulant dans le sang ont été plus nombreux chez les animaux traités avec l'uréthane. Les différences n'ayant pas été significatives, il n'a pas été possible de tirer des conclusions quant à l'influence ...

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Influence of Urethane on Susceptibility to Leukæmia Induction by Graffi Virus in Adult Mice

Cited by 21 publications

References 3 publications

Influence of Age on Susceptibility to Liver Carcinogenesis and Skin Initiating Action by Urethane in Swiss Mice

Influence of Age on Susceptibility to Liver Carcinogenesis and Skin Initiating Action by Urethane in Swiss Mice

Immunotoxicity of Pesticides

Effect of Sublethal Doses of Urethan in Adult Cattle

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