Influence of various agonists and antagonists on the release of free fatty acids from adipose tissue in vitro

Finger, Kenneth F.; Page, John G.; Feller, Dennis R.

doi:10.1016/0006-2952(66)90266-8

Cited by 22 publications

(9 citation statements)

References 18 publications

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“…Although their studies did not elucidate the mechanism underlaying the FFA elevation, the authors suggested that the effect on plasma FFA might be mediated through the central stimulating properties of these compounds. Both imipra mine and its desmethyl derivative stimulated a rise in plasma FFA which appeared to contradict the results of other investigations in vivo [6] and in vitro [7,14] that had shown antidepressant-in hibited lipolytic activity. It has previously been reported that desmethylimipramine (DMI) was capable of inhibiting catecholamineinduced FFA mobilization in vitro.…”

Section: Resultscontrasting

confidence: 55%

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The Effect of Desmethylimipramine and Theophylline on Plasma Free Fatty Acids and Blood Glucose in Rats

Page¹

1970

Pharmacology

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Section: Resultscontrasting

confidence: 55%

“…The effects of DM1 on free fatty acid (FFA) mobilization were studied in vitro [7] and later extended in vivo [6]. It was shown that DMI inhibited FFA mo bilization in vitro in a noncompetitive manner which suggested the possibility that DMI was combining at a nonadrenergic site to in hibit FFA release.…”

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confidence: 99%

The Effect of Desmethylimipramine and Theophylline on Plasma Free Fatty Acids and Blood Glucose in Rats

Page¹

1970

Pharmacology

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“…Khan et al (31) found that CPZ prevented the elevation of plasma FFA level in response to the stimuli of prolonged intermittent electric shocks. It has been also demonstrated that CPZ inhibited noradrenaline or adrenaline-stimulated lipolysis in vitro (8).…”

Section: Fig 4 Effects Of Chlorpromazine On the Noradrenaline-inducmentioning

confidence: 94%

“…A number of agents have been shown to inhibit lipolysis by inter fering with steps in the lipolytic process. Previous work has shown that chlorpromazine (CPZ) inhibits noradrenaline induced in vitro lipolysis in the rat epididymal fat (8). In vivo, CPZ also increases plasma FFA level (9,10).…”

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confidence: 99%

Effects of Chlorpromazine on Lipolysis in Brown and White Adipose Tissues of Cold-Exposed Rats

Uchida

1979

Japanese Journal of Pharmacology

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Abstract-Effectsof chlorpromazine (CPZ) on lipolysis in brown (interscapular: IBAT) and white (epididymal: EWAT) adipose tissues in cold-exposed rats were studied in vitro. Adult male Wistar-Imamichi rats were exposed to 4°C for 1 (acute cold-exposed) or 30 (cold-acclimated) days. The spontaneous free fatty acid (FFA) release from interscapular brown adipose tissue (IBAT) of control rats, was three fold higher than epididymal white adipose tissue (EWAT). FFA release from the EWAT of acute cold-exposed rats was significantly higher than that of control rats. After cold ac climation, FFA release from IBAT increased up to three times that of the control level. CPZ (10-', 10-3 M) suppressed the elevated lipolytic activity in IBAT of cold acclimated rats. However CPZ had no effect on FFA release from EWAT or IBAT in all other groups. A single intravenous administration of 10 mg/kg 6-hydroxy dopamine (6-OHDA) produced a marked decrease in the concentration of noradrenaline and dopamine in MAT and EWAT of cold-acclimated rats. FFA release from IBAT in 6-OHDA treated, cold-acclimated rats decreased to 50 % of untreated, cold-acclimated rats. A further decrease in lipolytic activity in the IBAT of 6-OHDA treated, cold-acclimated rats was produced following CPZ treatment. CPZ also depressed the lipolysis stimulated by the added noradrenaline (3 x 10-5 M). These results suggest that the effect of CPZ on the lipolysis in the IBAT from cold-acclimated rats is mediated by a modification of sympathetic activity.It is now generally accepted that the sympathetic nervous system plays an important role in the mobilization of free fatty acids (FFA) from adipose tissues.In particular, brown adipose tissue which is hypertrophied in cold-acclimated animals (1, 2) is intensively in nervated with sympathetic nerves in comparison to the white adipose tissue (3). The function of brown adipose tissue is to produce heat responding to the cold-stimulated release of noradrenaline from sympathetic nerve endings within the tissue (4-6). Free fatty acids following the augmented lipolysis may serve as essential substrates for thermogenesis in cold environments (7). A number of agents have been shown to inhibit lipolysis by inter fering with steps in the lipolytic process. Previous work has shown that chlorpromazine (CPZ) inhibits noradrenaline induced in vitro lipolysis in the rat epididymal fat (8). In vivo, CPZ also increases plasma FFA level (9, 10).We previously found that removal of interscapular brown adipose tissue (IBAT) po tentiated the hypothermia induced by CPZ injection in the cold-acclimated rats (11). This finding indicated that IBAT is involved in the CPZ induced hypothermia in the cold acclimated rat. Therefore, the following experiments were undertaken to determine the effects of CPZ on the stimulated lipolysis of adipose tissue which occurs during the cold exposure.Effects of chlorpromazine on the in vitro lipolysis were studied in the brown and white adipose tissues from control, acute cold-exposed and cold-acclimated rats. MAT...

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“…Incubations of fat pad* diid the determination of the rate of FFA release as function of agonist concentration were conducted by procedures previously described (9). pounds employed in this study arc prcscntcd in Pig.…”

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confidence: 99%

Interaction of Various Phenethylamines with the Adrenergic-Adipose Tissue Receptor System, In Vitro

Finger

Feller

1966

Journal of Pharmaceutical Sciences

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Influence of various agonists and antagonists on the release of free fatty acids from adipose tissue in vitro

Cited by 22 publications

References 18 publications

The Effect of Desmethylimipramine and Theophylline on Plasma Free Fatty Acids and Blood Glucose in Rats

The Effect of Desmethylimipramine and Theophylline on Plasma Free Fatty Acids and Blood Glucose in Rats

Effects of Chlorpromazine on Lipolysis in Brown and White Adipose Tissues of Cold-Exposed Rats

Interaction of Various Phenethylamines with the Adrenergic-Adipose Tissue Receptor System, In Vitro

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