Influence of Various Diets Administered by Gastric Gavage on Cariogenicity of Foods

Bowen, Willis H.; Amsbaugh, S.M.; Monell-Torrens, S.; Brunelle, Janet A.

doi:10.1159/000260713

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…This observa-variety ofdifferent diets by gavage had no effect on the cariogenicity tion is in line with that reported by Larson and Zickus (1972). Teeth of foods consumed per os (Bowen et al, 1983a).…”

Section: Remineralization Of Caries In Ratssupporting

confidence: 91%

“…not gain weight as well as do animals fed ad libitum (Bowen et al, 1980(Bowen et al, , 1983a. However, several physiological measurements indiThe majority ofsulcal E lesions developed during the first two weeks cate that the animals fed by gavage do not otherwise differ from of caries challenge; during the ensuing three weeks, the severity of conventionally fed animals.…”

Section: Remineralization Of Caries In Ratsmentioning

confidence: 99%

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The Effects of Sucralose, Xylitol, and Sorbitol on Remineralization of Caries Lesions in Rats

Bowen

Pearson

1992

J Dent Res

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The purpose of this study was to determine whether ingestion of sucralose, xylitol, sorbitol, or distilled water alone could enhance remineralization of early caries lesions in rats. Rats were infected by Streptococcus sobrinus, fed diet 2000 (Ziegler Brothers, Gardners, PA) ad libitum for two weeks, and, in addition, were offered drinking water sweetened by sucrose (10% w/v). A group of rats terminated at this time displayed significant levels of sulcal and smooth-surface caries. The remaining animals, for the ensuing three weeks, either continued on the same cariogenic challenge or received their essential nutrition by gavage and drank water, sweetened by one of the agents listed above, ad libitum. At the end of the additional three-week period, animals receiving sucralose, xylitol, sorbitol, or distilled water had fewer lesions than did the animals terminated after the two-week cariogenic challenge. The results show that removal of the cariogenic challenge allowed remineralization to occur and that no sweetening agent was superior to another in this respect.

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Section: Remineralization Of Caries In Ratssupporting

confidence: 91%

Section: Remineralization Of Caries In Ratsmentioning

confidence: 99%

The Effects of Sucralose, Xylitol, and Sorbitol on Remineralization of Caries Lesions in Rats

Bowen

Pearson

1992

J Dent Res

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“…We have reported previously that weight gains in the ani mals is low [Bowen et al, 1983[Bowen et al, ,1988; however, this is with out effect on the experimental outcome in a well-controlled study. Previous results from this laboratory have demon strated the cariostatic effect of iron when added by co-crys tallization with sucrose at concentrations as low as 88 ppm Fe [Bowen and Pearson, 1992;Rosalen et al, 1996].…”

Section: Discussionmentioning

confidence: 82%

“…The plain-sucrose group had a significantly higher percentage of S. sobrinus in the total cultivable flora. [Bowen et al, 1983[Bowen et al, ,1988, We chose to use the desalivated model because it repre sents a particularly severe challenge. We believe that any agent that prevents caries in this model has a high probabil ity of success when tested in humans.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Frequency of Exposure to Iron-Sucrose on the Incidence of Dental Caries in Desalivated Rats

1997

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World Health Organization (WHO) estimates that 2.5 billion people have anemia caused by iron deficiency that could be prevented by fortification of food; sugar, for example, has been used successfully as a vehicle for dietary iron fortification. The inclusion of 88 ppm of iron (as FeSO₄) co-crystallized with sugar has been shown to reduce the incidence of caries by more than 30% when rats are fed 17 meals daily at hourly intervals. The purpose of the present study was to determine the influence of varying the number of daily exposures to iron on caries in desalivated rats. Four litters of 12 Sprague-Dawley rats were desalivated when aged 25 days and caged in a programmed feeder. All animals received their essential nutrition by gavage and 17 meals of sucrose daily. In Group A, 6 meals contained 88 ppm Fe; in Group B, 3 meals contained iron; Group C had 2 meals, and in Group D, no iron was added. The investigation continued for 3 weeks. Smooth-surface and sulcal (in parentheses) caries scores were: Group A 60.8 (39.4); Group B 72.4 (41.3); Group C 73.1 (41.3), and Group D 92.9 (49.2). Caries scores in all the iron groups were statistically lower than in the control group. Severity scores followed a similar pattern. Thus, as few as 2 daily exposures to iron-sucrose had a significant effect on caries development; therefore the use of iron as a cariostatic agent is worthy of further exploration. The concept that two major public health problems could be alleviated by the addition of iron to sucrose is indeed attractive.

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Assessing the Cariogenic Potential of Some Infant Formulas, Milk and Sugar Solutions

Bowen¹,

Pearson²,

Rosalen³

et al. 1997

The Journal of the American Dental Association

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Influence of Various Diets Administered by Gastric Gavage on Cariogenicity of Foods

Cited by 3 publications

References 6 publications

The Effects of Sucralose, Xylitol, and Sorbitol on Remineralization of Caries Lesions in Rats

The Effects of Sucralose, Xylitol, and Sorbitol on Remineralization of Caries Lesions in Rats

Effects of Frequency of Exposure to Iron-Sucrose on the Incidence of Dental Caries in Desalivated Rats

Assessing the Cariogenic Potential of Some Infant Formulas, Milk and Sugar Solutions

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