Influence of Vero Cell Culture Synchronization on the Results of Cytotoxic Tests in the Study of New Medicines

Abstract

In this investigation used the method of serum starvation to synchronize the culture of Vero cells at the G0/G1. The synchronization efficiency was 40 %, the elongation coefficient was 1,657 ± 0,26, and the flattening coefficient was 1,399 ± 0,123. Cell synchronization provides to get a population of cells that respond identically in a narrow dose range and are more resistant to toxic effects.