Influence of viral load and genotype in the progression of Hepatitis B‐associated liver cirrhosis to hepatocellular carcinoma

Mahmood, Sabina; Niiyama, Gouichi; Kamei, Ayumi; Izumi, Akiyoshi; Nakata, Kohei; Ikeda, Hideji; Suehiro, Mitsuhiko; Kawanaka, Miwa; Togawa, Kazumi; Yamada, Gotaro

doi:10.1111/j.1478-3231.2005.01077.x

Cited by 53 publications

(41 citation statements)

References 31 publications

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“…This may explain our finding that HBV-DNA level was not a factor for hepatic decompensation and HCC development. Using highly sensitive HBV-DNA assays, a control study showed that persistent HBV-DNA >5 · 10 3 copies/ml was associated with increased risk of HCC [17] and a cohort study showed that HBV viral load was the only predictor of HCC development [18]. However, earlier studies using hybridization assays also failed to show definite correlation between the incidence of HCC development and the status of HBV-DNA at enrollment [4,8,19,20].…”

Section: Discussionmentioning

confidence: 89%

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study

et al. 2007

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Purpose To elucidate the long-term natural course following the onset of cirrhosis in patients with chronic hepatitis B. Methods Ninety-three patients with chronic hepatitis B who had developed cirrhosis during regular follow-up were included in this long-term follow-up study. At the time of cirrhosis detection, 30% of the patients were seropositive for hepatitis B e antigen (HBeAg) and 73% had a HBV-DNA level >10 4 copies/ml. Follow-up studies included liver biochemistry, viral markers, a-fetoprotein and ultrasonography every 3-6 months. Results During a mean follow-up period of 102 ± 60 (12-246; median 97) months, 32 patients (34.4%) experienced 55 episodes of hepatitis flare (7.0%/year), 15 (53.6%) of 28 HBeAg-positive patients seroconverted to anti-HBe (6.3%/yr) and 12 (12.9%) lost HBsAg (1.5%/year). Overall disease progression was observed in 25 (26.9%, 3.2%/year) patients: 12 (12.9%, 1.5%/ year) hepatic decompensation, 21 (22.6%, 2.7%/year) hepatocellular carcinoma and 11 (11.8%, 1.4%/year) died. Multivariate analysis showed that age at onset of cirrhosis (P = 0.015) and persistent HBeAg seropositivity (P = 0.019) were the independent factors for overall disease progression. Conclusions These results suggest that patients with older age at onset of cirrhosis and persistent HBeAg seropositivity following the onset of cirrhosis were independent factors for the disease progression in the first 10-year after the development of cirrhosis in patients with chronic hepatitis B.

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Section: Discussionmentioning

confidence: 89%

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study

et al. 2007

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“…Fourth, the ALT level was not evaluated in the present study. However, in the previous study about the pattern of HBV DNA and ALT level, the value of cancer prediction was much higher in the assay of HBV DNA than that of ALT [6,7] .…”

Section: Discussionmentioning

confidence: 99%

“…First, the majority of studies assess the serum HBV DNA level at a single time at study entry rather than at multiple time points or at the time of HCC development. However, there is little information on the changing pattern of the serial HBV DNA levels [6,7] , although recent data from the REVEAL-HBV study demonstrated that persistently elevated serum HBV DNA levels at more than two time points is a strong predictor of HCC risk [2,8,9] . Therefore, serial pattern analysis would be important in measurement of HCC risk; data from only two points including baseline and last follow-up are inadequate.…”

Section: Introductionmentioning

confidence: 99%

Impact of Serial Hepatitis B Virus DNA on Hepatocellular Carcinoma Development in Patients with Liver Cirrhosis

Kwon¹,

Choi²,

Jang³

et al. 2009

Intervirology

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“…Viral, host (sex, age and genetic susceptibility) and environmental factors may play interactive roles in hepatocarcinogenesis [7][8][9][10][11][12] . Recent studies have indicated that serum level of HBV DNA may be a risk factor for HCC [13][14][15][16] . Tang et al [17] have previously reported that adult HBV carriers who maintain high-titer serum HBV DNA are at higher risk for development of HCC.…”

Section: Introductionmentioning

confidence: 99%

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

Liu¹,

Fāng²,

Xiong³

et al. 2008

WJG

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AIM:To investigate the role of hepatitis B virus (HBV) replication in the development of hepatocellular carcinoma (HCC), a nested case-control study was performed to study the relationship between HBV DNA level and risk of HCC. METHODS:One hundred and seventy cases of HCC and 276 control subjects free of HCC and cirrhosis were selected for this study. Serum HBV DNA level was measured using fluorescein quantitative polymerase chain reaction at study entry and the last visit. RESULTS:In a binary unconditional logistic regression analysis adjusted for age, cigarette smoking, alcohol consumption and family history of chronic liver diseases, the adjusted odds ratios (95% confidence intervals) of HCC in patients with increasing HBV DNA level were 2.834 (1.237-6.492), 48.403 (14.392-162.789), 42.252 (14.784-120.750), and 14.819 (6.992-31.411) for HBV DNA levels ≥ 10 4 to < 10 5 ; ≥ 10 5 to < 10 6 ; ≥ 10 6 to < 10 7 ; ≥ 10 7 copies/mL, respectively. Forty-six HCC cases were selected to compare the serums viral loads of HBV DNA at study entry with those at the last visit. The HBV DNA levels measured at the two time points did not differ significantly.

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Influence of viral load and genotype in the progression of Hepatitis B‐associated liver cirrhosis to hepatocellular carcinoma

Abstract: Patients with genotype C and a continuously high HBV DNA for 5 years or more are at a high-risk group for HCC development. Maintaining continuously low HBV DNA for 3 years or more with anti-viral therapy, may be useful in preventing or delaying HCC occurrence.

Cited by 53 publications

References 31 publications

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study

Impact of Serial Hepatitis B Virus DNA on Hepatocellular Carcinoma Development in Patients with Liver Cirrhosis

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China

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