Influence of Viscosity and Solubilization on Dissolution Rate

Dissolution of Two-Component Solids

“…Dissolution Rate-The dissolution rate was determined in distilled water at 25 f 0.1", as previously described (17,19), under conditions where the concentration of the solute did not exceed 5% of its solubility. The dissolution apparatus consisted of a 2-liter beaker in which a 3.0 X 1.5-cm stainless steel paddle was positioned 6.0 cm from the bottom of the beaker.…”

Effect of Various Parameters Upon Diffusion-Controlled Dissolution of Benzoic Acid

“…In an investigation of the dissolution kinetics of benzoic acid in micellar solutions, the relationship of dissolution rate, solubilization, and viscosity was determined (5). As shown in Fig.…”

“…The viscosity of the micellar solution is not greatly increased by the surfactant at low concentrations of polysorbate 80; however, at concentrations exceeding 8 75 polysorbate 80, the viscosity is greatly increased by the surfactant (5).…”

“…gation the concomitant and individual effects of solubilization and viscosity on dissolution rate were reported (5). Although at constant viscosity the dissolution rate was roughly proportional to the total solubility, as depicted by the Noyes-Whitney relation, this investigation sought to study the deviation in terms of the contribution of the diffusion coefficient of benzoic acid and the diffusion coefficient of solubilized benzoic acid to the observed dissolution rate in various concentrations of polysorbate 80.…”

“…cooficieirt of beiiroic acid to its niicc~llcir solubility iir uquoous polysorbute 80 solurioirs adjusted with sucrose to u relutice viscosity of 3.95 5. 10 15C.…”