Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review

Guzek, Dominika; Kołota, Aleksandra; Lachowicz, Katarzyna; Skolmowska, Dominika; Stachoń, Małgorzata; Głąbska, Dominika

doi:10.3390/nu13113678

Cited by 12 publications

(10 citation statements)

References 39 publications

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“…The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42020155779), within the common registration with the previous studies, which covered the influence of vitamin D on mental health in healthy children [ 22 ], as well as in adults with diabetes [ 23 ] and in adults with inflammatory bowel diseases and irritable bowel syndrome [ 24 ]. The systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [ 25 ] for the systematic literature search, screening, inclusion, and reporting.…”

Section: Methodsmentioning

confidence: 99%

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Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review

Guzek

Kołota

Lachowicz

et al. 2021

JCM

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Vitamin D is considered to be a crucial factor that influences symptoms of depression, negative emotions, and quality of life, but to date, no systematic review has been conducted with regard to its effect on other domains of mental health. The aim of the study was to evaluate the influence of vitamin D supplementation on mental health in healthy adults. The systematic review was registered in the PROSPERO database (CRD42020155779) and performed according to the PRISMA guidelines. The literature search was conducted in PubMed and Web of Science databases and included intervention studies published until October 2019. The human studies were included if the supplementation regimen involved the administration of a specified dosage of vitamin D to an adult sample. A total of 7613 records were screened and assessed independently by two researchers, based on their title, abstract, and full text sequentially. Finally, 14 studies were included, and their risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The studies were included if they presented the results of various doses of vitamin D, compared the supplementation results with the placebo effect, compared the outcome with no supplementation, or observed effect of specific dose applied. The assessed mental health outcomes mainly included depressive symptoms, or depression, well-being, quality of life, mood, general mental component, and anxiety, but single studies also included other parameters such as distress, impression of improvement, and fear of falling and flourishing. The results of the majority of studies did not confirm a positive influence of vitamin D supplementation. None of the high-quality studies (assessed using NOS), which evaluated outcomes other than depression, supported the hypothesis that vitamin D supplementation effectively ameliorates mental health issues, while they present conflicting evidence for depression. Some studies indicated that supplementation should be combined with physical activity to provide effective results, and that supplementation is less effective than vitamin D supply from food sources. The included studies were conducted in diverse populations and followed various doses and intervals of administration, so the results may be incomparable, which should be considered as a limitation. The conducted systematic review did not provide strong evidence for a positive effect of vitamin D supplementation on mental health in healthy adults.

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Section: Methodsmentioning

confidence: 99%

“… The inclusion procedure to the systematic review developed based on PRISMA 2009 flow diagram [ 23 ]. …”

Section: Figurementioning

confidence: 99%

Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review

Guzek

Kołota

Lachowicz

et al. 2021

JCM

Self Cite

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“…Evidence supporting the use of vitamin and mineral supplements for the treatment or prevention of non-communicable diseases, such as cardiovascular disorders or cancer, is inadequate ( 15 , 16 ). However, supplementation has been shown to be beneficial in the treatment of various commonly occurring diseases such as diabetes, obesity, and mental illness ( 17 – 19 ). The effect of DS can be determined by several factors, such as the type, dose, and chemical composition of the preparation, usage period, and regularity.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle, Eating Habits, and Health Behaviors Among Dietary Supplement Users in Three European Countries

Iłowiecka

Maślej²,

Czajka³

et al. 2022

Front. Public Health

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Dietary supplements (DS) are used by about 30–50% of adults in developed countries. However, only a few studies have compared the characteristics of DS users in different nations. This study aimed to identify and compare selected health-related behaviors of DS users from three European countries. A total of 3,588 adults (32.08 ± 8.04 years) from Poland (1,030 females, 287 males), Germany (994 females, 190 males), and the United Kingdom (911 females, 176 males) were included in the analysis. The study was based on a self-administered survey consisting of 70 questions regarding baseline characteristics, lifestyle, eating, and health habits. The associations of the obtained results were compared using the Kruskal–Wallis test, Pearson Chi-Square test, and Cramer's V value. The highest percentage of DS users (56.98%, n = 2,044) had a correct body weight, while higher body weight values were observed in 39.19% (n = 1,406). In terms of lifestyle, statistically significant differences (p < 0.05) were noted for alcohol consumption and the level of physical activity. Fruit and vegetables were most often consumed a few times a weeks (34.67%, n = 1,244). A similar result was observed for the consumption of whole grain (37.76%, n = 1,355), dairy (39.99%, n = 1,435), eggs (49.67%, n = 1,782), and meat (51.45%, n = 1,846). Most DS users did not have a chronic disease (66.72%, n = 2,394). Among the other conditions, a frequent occurrence (a few times a weeks) of gastrointestinal problems (28.29%, n = 1,015) and concentration disorders (29.15%, n = 1,046) was noted. Cramer's V values (<0.3) indicated a weak (but significant p < 0.05) relationship between the country of residence and most of the analyzed variables. In conclusion, DS users were characterized by a healthy lifestyle with appropriate behaviors but not healthy eating habits.

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“…For the studies included within the second stage, the additional searching of the COVID-19 incidence information in the studied group was conducted. The procedure applied was based on a previously adapted one for the assessment of vitamin D on mental health in children [ 21 ] and adults [ 22 ], including populations with diabetes [ 23 ], multiple sclerosis [ 24 ], as well as inflammatory bowel diseases and irritable bowel syndrome [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Depression in Adults: A Systematic Review of Randomized Controlled Trials (RCTs)

et al. 2023

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Vitamin D is a nutrient potentially beneficial in the treatment of depression. The study aimed to carry out a systematic review of the studies assessing the influence of vitamin D supplementation on depression within Randomized Controlled Trials (RCTs). The systematic review was prepared on the basis of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42020155779). The peer-reviewed studies available within PubMed or Web of Science databases until September 2021 were taken into account. The number of screened records was 8514, and 8 records were included. Two independent researchers conducted screening, including, reporting, and risk of bias assessment using the revised Cochrane risk-of-bias tool for randomized trials. The included studies presented a population of patients with major depressive disorders or general depression, as well as bipolar depression or postpartum depression. The majority of included studies were conducted for 8 weeks or 12 weeks, while one study was conducted for 6 months. Within the large number of included studies, a daily dose of 1500 IU, 1600 IU, or 2800 IU was applied, while within some studies, a vitamin D dose of 50,000 IU was applied weekly or biweekly. Among applied psychological measures of depression, there were various tools. In spite of the fact that the majority of included studies (five studies) supported the positive effect of vitamin D supplementation for the psychological measure of depression, for three studies the positive influence was not supported. A medium risk of bias was indicated for six studies, while a high risk of bias was defined for only two studies, due to deviations from the intended interventions and in measurement of the outcome, as well as for one study, also arising from the randomization process and due to missing outcome data. Based on conducted assessment, it should be emphasized that there are only four studies supporting the positive influence of vitamin D supplementation for the psychological measure of depression of the medium risk of bias, while two studies of a medium risk of bias did not support it. Taking this into account, the conducted systematic review is not a strong confirmation of the effectiveness of vitamin D supplementation in the treatment of depression.

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Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review

Cited by 12 publications

References 39 publications

Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review

Association between Vitamin D Supplementation and Mental Health in Healthy Adults: A Systematic Review

Lifestyle, Eating Habits, and Health Behaviors Among Dietary Supplement Users in Three European Countries

Effect of Vitamin D Supplementation on Depression in Adults: A Systematic Review of Randomized Controlled Trials (RCTs)

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