Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

Patrice, Thierry; Rozec, Bertrand; Sidoroff, Alexis; Blanlœil, Y.; Despins, Philippe; Perrigaud, Christian

doi:10.3390/diseases4030025

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…In “early” lung cancers, secondary reactive oxygen species (SOSs) are comparable or inferior to that of healthy people. The role of vitamins varies with gender, type of cancer and metastasis [7].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants: Positive or Negative Actors?

et al. 2018

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The term “antioxidant” is one of the most confusing definitions in biological/medical sciences. In chemistry, “antioxidant” is simply conceived “a compound that removes reactive species, mainly those oxygen-derived”, while in a cell context, the conceptual definition of an antioxidant is poorly understood. Indeed, non-clinically recommended antioxidants are often consumed in large amounts by the global population, based on the belief that cancer, inflammation and degenerative diseases are triggered by high oxygen levels (or reactive oxygen species) and that through blocking reactive species production, organic unbalances/disorders can be prevented and/or even treated. The popularity of these chemicals arises in part from the widespread public mistrust of allopathic medicine. In fact, reactive oxygen species play a dual role in dealing with different disorders, since they may contribute to disease onset and/or progression but may also play a key role in disease prevention. Further, the ability of the most commonly used supplements, such as vitamins C, E, selenium, and herbal supplements to decrease pathologic reactive oxygen species is not clearly established. Hence, the present review aims to provide a nuanced understanding of where current knowledge is and where it should go.

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Section: Introductionmentioning

confidence: 99%

Antioxidants: Positive or Negative Actors?

et al. 2018

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“…The significant (p<0.05) reduction in the cardiac MDA concentrations after the administration of different doses of the fraction indicate cardio-protective potency of Cola hispida leaf fraction against the Doxinduced lipid peroxidation [33]. This protective effect of Cola hispida leaf could be attributed to its antioxidant property, thus ethyl acetate fraction of Cola hispida leaf could be used to restore affected biochemical profiles induced by Dox exposure or any other cardiotoxic substance to enhance membrane stabilization [34]. Also, the presence of phytochemicals and secondary metabolites could be responsible for the antioxidant activity of the fraction [26,35] (Table 4).…”

Section: Discussionmentioning

confidence: 97%

Ethyl acetate fraction of Cola hispida leaf protects against doxorubicin-induced myocardial injury in male albino rats

2021

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Background Cardiovascular diseases have continued to be the leading cause of death globally. In addition, some of the drugs used in the treatment of the diseases present some adverse effects which limit the usefulness of such drugs. Thus, there is a need for novel drugs whose side effect is either minimal or non-existent. The presence of bioactive compounds in Cola hispida leaf is of great significance in the treatment and management of cardiovascular conditions. This study investigated the cardio-protective potential against doxorubicin (Dox)-induced cardiac infarction in rats. Results Dox induction resulted to muscle fiber degeneration in Dox-treated rats hence revealed significant (p < 0.05) elevation in the serum level of cardio biomarker enzymes and lipid peroxidation profile while significant (p < 0.05) fall in cardiac enzymatic antioxidant levels were observed relative to the normal control. Pre-treatment with ethyl acetate fraction of Cola hispida leaf expressed cardio-protective potentials against Dox-induced cardiotoxicity by significantly (p < 0.05) lowering the levels of cardiac biomarker enzymes towards normal, building up the activities of subdued antioxidant enzymes and depleting its malondialdehyde level. Histopathology photomicrograph of the heart tissues expressed myxomatous degeneration but was ameliorated through the administration of the fraction. Conclusion In accordance with the findings from this study, the administration of ethyl acetate fraction of Cola hispida leaf is effective against Dox-induced redox imbalance due to its enriched antioxidant phytoconstituents.

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“…Para el complejo SDQCu, en la concentración de 2.0 µM la viabilidad se recuperó 22%, a 3.0 µM 10.4% y finalmente a 4.0 µM 6.9%. La recuperación de la viabilidad puede ser asociada a la neutralización de los ROS por parte de las vitaminas [349,350]. Lo que podría explicar parcialmente el mecanismo de muerte que ejercen los complejos SMTCu y SDQCu.…”

Section: Figura 53-20 Resultados Del Ensayo Cometa En Células A549 Eunclassified

Screening de metalofármacos derivados de N-heterociclos y metales de transición en cultivos celulares 2D y 3D según sus efectos antitumorales

Vargas¹,

Fernando²

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El desarrollo de fármacos es un proceso complejo el cual inicia con la identificación de compuestos que muestran actividad biológica en un ensayo de tamizaje. La mayoría de los medicamentos que están en uso clínico son el resultado de un proceso de investigación muy complejo. Por ello, es necesaria la unión de esfuerzos de diferentes disciplinas científicas para descubrir y desarrollar medicamentos con efectos clínicos benéficos y efectos secundarios mínimos. Se estima que de cada 9.000 moléculas biológicamente activas solo una tiene uso clínico. Los resultados presentados en este trabajo de tesis doctoral indican que los complejos de cobre(II) estudiados ejercen sus efectos citotóxicos a través de mecanismos de muerte que conllevan a un aumento del estrés oxidativo, una disminución de los niveles de GSH con el consecuente arresto del ciclo celular y/o la inducción de apoptosis. Asimismo, estos compuestos inducen genotoxicidad provocada por un daño oxidativo a nivel del ADN. En modelos tridimensionales de células tumorales, también se pudieron encontrar efectos citotóxicos y sobre la invasión celular. Por otro lado, cabe destacar que la eficacia de los compuestos tamizados aumenta con la cantidad admitida de cobre que está asociada a su vez con la lipofilicidad (y con las estructuras químicas). Los complejos ternarios con 2,2´biquinolina, SMTCu y SDQCu, resultaron ser los complejos más prometedores, ya que no solo se destacan del resto de los complejos de cobre de las otras familias estudiadas en forma individual sino incluso supera a Cu6MQ en mezcla uno a uno con Zn6MQ. Asimismo, de los complejos de cobre con sulfonamidas, solo SDQCu, muestra un efecto sinérgico en un tratamiento combinado con radioterapia.

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Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

Cited by 8 publications

References 42 publications

Antioxidants: Positive or Negative Actors?

Antioxidants: Positive or Negative Actors?

Ethyl acetate fraction of Cola hispida leaf protects against doxorubicin-induced myocardial injury in male albino rats

Screening de metalofármacos derivados de N-heterociclos y metales de transición en cultivos celulares 2D y 3D según sus efectos antitumorales

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