Influence of water immersion stress on peripheral nerve recovery in the rat

Amako, Masatoshi; Nemoto, Koichi

doi:10.1007/s007760050019

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…For the evaluation of motor function, walking tracks were recorded as previously mentioned [12]. The following measurements were taken: the distance from heel to toe (the print length, PL), the distance between the first and fifth toes (the toe spread, TS), and the distance from the second to the fourth toes (the intermediary toe spread, IT).…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effect of Exendin-4, a Long-Acting Analogue of Glucagon-Like Peptide-1 Receptor Agonist, on Nerve Regeneration after the Crush Nerve Injury

Yamamoto

Amako

Yamamoto

et al. 2013

BioMed Research International

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Glucagon-like peptide-1 (GLP-1) is glucose-dependent insulinotropic hormone secreted from enteroendocrine L cells. Its long-acting analogue, exendin-4, is equipotent to GLP-1 and is used to treat type 2 diabetes mellitus. In addition, exendin-4 has effects on the central and peripheral nervous system. In this study, we administered repeated intraperitoneal (i.p.) injections of exendin-4 to examine whether exendin-4 is able to facilitate the recovery after the crush nerve injury. Exendin-4 injection was started immediately after crush injury and was repeated every day for subsequent 14 days. Rats subjected to sciatic nerve crush exhibited marked functional loss, electrophysiological dysfunction, and atrophy of the tibialis anterior muscle (TA). All these changes, except for the atrophy of TA, were improved significantly by the administration of exendin-4. Functional, electrophysiological, and morphological parameters indicated significant enhancement of nerve regeneration 4 weeks after nerve crush. These results suggest that exendin-4 is feasible for clinical application to treat peripheral nerve injury.

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Section: Methodsmentioning

confidence: 99%