The effects of water droplets on autoignition and detonation development induced by ignition spot with thermal inhomogeneity in n-C7H16/air mixture are numerically investigated. The Eulerian-Eulerian method considering gas-liquid two-way coupling is applied. Three initial water droplet diameters are considered, i.e., 5, 10 and 20 μm. Zero-dimensional two-phase homogeneous ignitions under the constant-volume condition are studied first. Different ignition delay time and evaporation time scales are highlighted. It is seen that of 5 μm shows nonmonotonic change with ,0 , indicating the NTC behaviours due to the water droplet addition. However, for 10 and 20 μm, increased ,0 leads to monotonically increased . Then, onedimensional two-phase autoignition and detonation development caused by temperature gradients in ignition spots is then discussed. It is found that conventional classification (i.e., (I) supersonic deflagrative wave, (II) detonative wave and (III) subsonic deflagrative wave) is also suitable for droplet laden mixtures. However, new regimes are observed for 5 μm.