Influence of whole-body vibration on biodistribution of the radiopharmaceutical [^99mTc]methylene diphosphonate in Wistar rats

Abstract

The analysis of the results indicates that the vibration could produce metabolic alterations with influence in the uptake of the radiopharmaceutical 99mTc-MDP in bone, stomach, bowel, prostate, kidney and bladder.

Whole body vibration exercise combined with an extract ofCoriandrum sativummodify some biochemical/physiological parameters in rats

“…Previously, Pereira et al [22] have shown that, in rats, the exposure to vibration with 20 Hz can alter the uptake of a radiopharmaceutical in some organs. Frederico et al [16] reported that the association between coriander and WBV (12 Hz) increases the uptake of Na 99m TcO 4 in spleen.…”

“…The biological effects of the WBV exercises in an organ seem to be also dependent on the frequency [16,22]. Miyazaki, 2000 has evaluated the electrogastrography (EGG) in healthy male volunteers’ exposure to vibrations of 4, 8, and 16 Hz.…”

“…After 10 min, sample of blood was obtained from by cardiac puncture and used for biochemical analysis. Following, the animals were killed (CO 2 asphyxiation) (CONCEA, 2013), the organs (thyroid, stomach, bowel, kidney, liver, pancreas, brain, bone, lung, heart, spleen, muscle, penis, prostate, seminal vesicle, bladder, testis, and blood) were isolated, the radioactivity determined in a well counter, and the percentages of injected radioactivity per gram (%ATI/g) in the organs were calculated as reported elsewhere [22]. …”

“…One of the possible ways to study these vibrations in tissues/organs, it is by evaluating the biodistribution of radiopharmaceuticals, as already described for physical activity [19], chemical [20], and physical (laser) agents [21]. Pereira et al [22] (vibration with 20 Hz) and Frederico et al [16] (vibration with 12 Hz) reported the effect of WBV exercise in the biodistribution of radiopharmaceuticals in rats using a side-alternating platform.…”

Biological Effects of Paullinia cupana (Guarana) in Combination with Whole-Body Vibration Exercise in Wistar Rats

“…This increase could possibly be due to the caffeine, a component of guarana [4]. According to Behrens et al [38], the ingestion of caffeine induced increases in the voluntary activation and strength of the quadriceps muscle during isometric, concentric, and eccentric contractions. Furthermore, in general, the interventions did not promote modifications at different levels (molecular or cellular) in the several organs that were capable of interfering in the uptake of the radiopharmaceutical Na 99m TcO 4 .…”