Influence of zero-burning policy and climate phenomena on ambient PM2.5 patterns and PAHs inhalation cancer risk during episodes of smoke haze in Northern Thailand

Yabueng, Nuttipon; Wiriya, Wan; Chantara, Somporn

doi:10.1016/j.atmosenv.2020.117485

Cited by 41 publications

(47 citation statements)

References 38 publications

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“…Besides, PYR was also the highest species found in the outdoor samples of school C1. The higher fraction of HMW PAHs could be influenced by the degree of solvent extraction efficiency [ 55 ]. In this study, dichloromethane and n-hexane had similar polarity properties as the HMW PAHs, thus favouring the excellent extraction efficiency of the heavier PAH component.…”

Section: Resultsmentioning

confidence: 99%

Exposure to Particulate PAHs on Potential Genotoxicity and Cancer Risk among School Children Living Near the Petrochemical Industry

Sopian

Jalaludin

Bakar

et al. 2021

IJERPH

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This study aimed to assess the association of exposure to particle-bound (PM2.5) polycyclic aromatic hydrocarbons (PAHs) with potential genotoxicity and cancer risk among children living near the petrochemical industry and comparative populations in Malaysia. PM2.5 samples were collected using a low-volume sampler for 24 h at three primary schools located within 5 km of the industrial area and three comparative schools more than 20 km away from any industrial activity. A gas chromatography–mass spectrometer was used to determine the analysis of 16 United States Environmental Protection Agency (USEPA) priority PAHs. A total of 205 children were randomly selected to assess the DNA damage in buccal cells, employing the comet assay. Total PAHs measured in exposed and comparative schools varied, respectively, from 61.60 to 64.64 ng m−3 and from 5.93 to 35.06 ng m−3. The PAH emission in exposed schools was contributed mainly by traffic and industrial emissions, dependent on the source apportionment. The 95th percentiles of the incremental lifetime cancer risk estimated using Monte Carlo simulation revealed that the inhalation risk for the exposed children and comparative populations was 2.22 × 10−6 and 2.95 × 10−7, respectively. The degree of DNA injury was substantially more severe among the exposed children relative to the comparative community. This study reveals that higher exposure to PAHs increases the risk of genotoxic effects and cancer among children.

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Section: Resultsmentioning

confidence: 99%

Exposure to Particulate PAHs on Potential Genotoxicity and Cancer Risk among School Children Living Near the Petrochemical Industry

Sopian

Jalaludin

Bakar

et al. 2021

IJERPH

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“…The PMFF samples were analyzed, and the concentrations of the 15 measured PAHs ranged from 0 to 2.094 ng/m 3 , with the highest component of PAHs being 2.094 ng/m 3 of benzo[ghi]perylene, followed by, in order, indeno[1,2,3,-cd]pyrene, benzo[b]fluoranthene, and benzo[a]pyrene. Similarly, several studies in northern Thailand found that PM-bound PAHs were highly contaminated in the burning period [26,[44][45][46][47].…”

Section: Discussionmentioning

confidence: 82%

“…To determine whether exposure to PAHs might cause significant effects in humans, health risk assessments can be calculated from the toxicity equivalent concentration (TEQ) based on PAH concentrations and toxic equivalent factors (TEFs) [26,48,49]. We found that the TEQ values in our study by using two equations as references from U.S. EPA (1993) [48] and Cecinato (1997) [49] were 1.37 ng/m 3 and 1.69 ng/m 3 , respectively.…”

Section: Discussionmentioning

confidence: 99%

“…The sampling area was near a forest fire incident. After sampling, PAH compounds including acenaphthene, acenaphthylene, anthracene, benz[a]anthracene, benzo[a]pyrene, benzo[b]fluoranthene, benzo[ghi]perylene, benzo[k]fluoranthene, chrysene, dibenz[a,h]anthracene, fluoranthene, fluorene, indeno[1,2,3-cd]pyrene, naphthalene, phenanthrene, and pyrene were determined using an Agilent 7820A gas chromatograph coupled to an Agilent 5977E [26].…”

Section: Pmff Sampling and Gc-ms Analysismentioning

confidence: 99%

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Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-Κb and Akt Signaling Pathways

et al. 2021

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Particulate matter from forest fires (PMFF) is an environmental pollutant causing oxidative stress, inflammation, and cancer cell metastasis due to the presence of polycyclic aromatic hydrocarbons (PAHs). Perilla seed meal contains high levels of polyphenols, including rosmarinic acid (RA). The aim of this study is to determine the anti-oxidative stress, anti-inflammation, and anti-metastasis actions of rosmarinic acid rich fraction (RA-RF) from perilla seed meal and its underlying molecular mechanisms in A549 cells exposed to PMFF. PMFF samples were collected via the air sampler at the University of Phayao, Thailand, and their PAH content were analyzed using GC-MS. Fifteen PAH compounds were detected in PMFF. The PMFF significantly induced intracellular reactive oxygen species (ROS) production, the mRNA expression of pro-inflammatory cytokines, MMP-9 activity, invasion, migration, the overexpression of c-Jun and p-65-NF-κB, and Akt phosphorylation. Additionally, the RA-RF significantly reduced ROS production, IL-6, IL-8, TNF-α, and COX-2. RA-RF could also suppress MMP-9 activity, migration, invasion, and the phosphorylation activity of c-Jun, p-65-NF-κB, and Akt. Our findings revealed that RA-RF has antioxidant, anti-inflammatory, and anti-metastasis properties via c-Jun, p-65-NF-κB, and Akt signaling pathways. RA-RF may be further developed as an inhalation agent for the prevention of lung inflammation and cancer metastasis induced by PM exposure.

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“…It can be revealed that zero burning policy in that year was effective according to density of fire hotspot counts as well as level of PM2.5 during an implementation period. However, high number of active fire hotspots was found in both agricultural and forest areas after the policy period was ended, resulting in longer smoke haze duration [34].…”

Section: ) Health Risk Assessment Based On Pahs Toxicitymentioning

confidence: 99%

Characterization of PM2.5–bound Polycyclic Aromatic Hydrocarbons in Chiang Mai, Thailand during Biomass Open Burning Period of 2016

Thepnuan

Chantara

2020

App. Envi. Res.

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Polycyclic aromatic hydrocarbons (PAHs) bounded to ambient fine particles (PM2.5) were determined for enabling health risk assessment and source identification of ambient aerosols. Daily PM2.5 samples (24 h) were collected on quartz fiber filters by using a low volume air sampler (16.7 L min-1) during smoke haze period (March–April 2016) in Chiang Mai, Thailand. An average concentration of PM2.5 (n=54) was 65.3±17.6 μg m-3. The samples were extracted with dichloromethane using ultrasonication prior to PAHs analysis by GC-MS. Average concentrations of 16-PAHs, non-carcinogenic (nc) PAHs and carcinogenic (c) PAHs were 10.23±2.49, 5.48±1.70 and 4.75±1.43 ng m-3, respectively. Ratio values of cPAHs/ncPAHs ranged from 0.44 to 1.98. Strong correlation (r= 0.76) between PM2.5 and cPAHs concentration was observed. Toxicity equivalent concentrations (TEQ) of PAHs was 1.13±0.34 ng m-3. The value of inhalation cancer risk (ICR) for exposure of ambient PAHs calculated from TEQ value was 1.0×10-4 indicating high risk for long term exposure. Diagnostic ratios (DRs) of various pairs of PAHs revealed that biomass burning is a major source during smoke haze period.

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Influence of zero-burning policy and climate phenomena on ambient PM2.5 patterns and PAHs inhalation cancer risk during episodes of smoke haze in Northern Thailand

Cited by 41 publications

References 38 publications

Exposure to Particulate PAHs on Potential Genotoxicity and Cancer Risk among School Children Living Near the Petrochemical Industry

Exposure to Particulate PAHs on Potential Genotoxicity and Cancer Risk among School Children Living Near the Petrochemical Industry

Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-Κb and Akt Signaling Pathways

Characterization of PM2.5–bound Polycyclic Aromatic Hydrocarbons in Chiang Mai, Thailand during Biomass Open Burning Period of 2016

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