Influence of β-Globin Haplotypes on Oxidative Stress, Antioxidant Capacity and Inflammation in Sickle Cell Patients of Chhattisgarh

Bhagat, Sanjana; Thakur, A. K.

doi:10.1007/s12291-017-0729-3

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…On this way, elevated level of OS results in oxidation of Cys/Met residues causes imbalances in the redox state of eye lens. Formation of high molecular weight totals, protein cross-linking by disulfide and non-disulfide bonds and protein insolubilization could be named as the examples [66] , [67] , [68] . Among all types ROS, species like H 2 O 2 , superoxide anion and nitrite radical species are the major factors as chain reaction initiators under many various conditions that are going to be defined and discussed in further subsections.…”

Section: Oxidative Stress Conceptmentioning

confidence: 99%

Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach

Ebrahimi

Norouzi

Aazami

et al. 2021

International Journal of Biological Macromolecules

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Section: Oxidative Stress Conceptmentioning

confidence: 99%

Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach

Ebrahimi

Norouzi

Aazami

et al. 2021

International Journal of Biological Macromolecules

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Genetic Variation and Sickle Cell Disease Severity

Kirkham,

Estepp,

Weiss

et al. 2023

JAMA Netw Open

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ImportanceSickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are influenced by additional genetic factors. Despite decades of research, the genetics of SCD remain poorly understood.ObjectiveTo assess all reported genetic modifiers of SCD, evaluate the design of associated studies, and provide guidelines for future analyses according to modern genetic study recommendations.Data SourcesPubMed, Web of Science, and Scopus were searched through May 16, 2023, identifying 5290 publications.Study SelectionAt least 2 reviewers identified 571 original, peer-reviewed English-language publications reporting genetic modifiers of human SCD phenotypes, wherein the outcome was not treatment response, and the comparison was not between SCD subtypes or including healthy controls.Data Extraction and SynthesisData relevant to all genetic modifiers of SCD were extracted, evaluated, and presented following STREGA and PRISMA guidelines. Weighted z score meta-analyses and pathway analyses were conducted.Main Outcomes and MeasuresOutcomes were aggregated into 25 categories, grouped as acute complications, chronic conditions, hematologic parameters or biomarkers, and general or mixed measures of SCD severity.ResultsThe 571 included studies reported on 29 670 unique individuals (50% ≤ 18 years of age) from 43 countries. Of the 17 757 extracted results (4890 significant) in 1552 genes, 3675 results met the study criteria for meta-analysis: reported phenotype and genotype, association size and direction, variability measure, sample size, and statistical test. Only 173 results for 62 associations could be cross-study combined. The remaining associations could not be aggregated because they were only reported once or methods (eg, study design, reporting practice) and genotype or phenotype definitions were insufficiently harmonized. Gene variants regulating fetal hemoglobin and α-thalassemia (important markers for SCD severity) were frequently identified: 19 single-nucleotide variants in BCL11A, HBS1L-MYB, and HBG2 were significantly associated with fetal hemoglobin (absolute value of Z = 4.00 to 20.66; P = 8.63 × 10−95 to 6.19 × 10−5), and α-thalassemia deletions were significantly associated with increased hemoglobin level and reduced risk of albuminuria, abnormal transcranial Doppler velocity, and stroke (absolute value of Z = 3.43 to 5.16; P = 2.42 × 10−7 to 6.00 × 10−4). However, other associations remain unconfirmed. Pathway analyses of significant genes highlighted the importance of cellular adhesion, inflammation, oxidative and toxic stress, and blood vessel regulation in SCD (23 of the top 25 Gene Ontology pathways involve these processes) and suggested future research areas.Conclusions and RelevanceThe findings of this comprehensive systematic review and meta-analysis of all published genetic modifiers of SCD indicated that implementation of standardized phenotypes, statistical methods, and reporting practices should accelerate discovery and validation of genetic modifiers and development of clinically actionable genetic profiles.

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Influence of β-Globin Haplotypes on Oxidative Stress, Antioxidant Capacity and Inflammation in Sickle Cell Patients of Chhattisgarh

Cited by 2 publications

References 32 publications

Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach

Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach

Genetic Variation and Sickle Cell Disease Severity

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