Influence on Implant Bone Healing of a Collagen Membrane Placed Subjacent the Sinus Mucosa—A Randomized Clinical Trial on Sinus Floor Elevation

Morimoto, Akira; Kobayashi, N.; Ferri, Mauro; Iezzi, Giovanna; Piattelli, Adriano; Mesa, Natalia Fortich; Botticelli, Daniele

doi:10.3390/dj10060105

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…The possibility of analyzing implants retrieved from the human maxilla after bone graft procedures and implant installation has rarely been reported in the literature [6][7][8][9][15][16][17][18][19]. The causes of implant retrieval in humans are usually attributable to implant fractures [15][16][17] or peri-implantitis [19].…”

Section: Discussionmentioning

confidence: 99%

“…The histological healing processes of various biomaterials for maxillary sinus floor elevation has been studied [3]. A series of bioptic clinical studies have reported data on the integration of mini-implants installed six months after sinus floor elevation and retrieved three months later [6][7][8][9]. These studies showed a low impact of both dimension and position of the access window on osseointegration.…”

Section: Introductionmentioning

confidence: 99%

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ESEM-EDX Mineralization and Morphological Analysis of Human Retrieved Maxillary Sinus Bone Graft Biopsies before Loading

Imai

Prati

Zamparini

et al. 2023

JFB

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This study aimed to analyze the morphology of bone graft granules, the presence of granule demineralization, and bone morphology in retrieved human maxillary sinus bone graft biopsies. Healthy patients underwent sinus bone augmentation using lateral access. Two different dimensions of the antrostomy were performed, a 4 mm or 8 mm height. After 6 months, all sites received one implant using a flap technique, crestal positioning, and submerged healing. Implant biopsies were retrieved after 3 months and were histologically processed. The ESEM analysis was performed on the entire portion of the peri-implant bone (up to 750 µm from the implant thread). Three different regions of interest (ROIs) were selected: the coronal, middle, and apical portions of the implant. In these areas, EDX was performed, and calcium (Ca), phosphate (P), nitrogen (N), and their atomic ratios (Ca/P, Ca/N, and P/N) were calculated. Different bone tissue electron-dense areas were detected through grayscale intensity quantification of ESEM images with different organic (N) or inorganic (Ca,P) compositions. A total of 16 biopsies from 16 healthy patients were analyzed. Bone graft granules were mostly detected in the apical ROI. New bone tissue bridges were detected in the apical and middle ROI. These structures, with lower Ca/N and P/N ratios, were connected and enveloped the bone graft granules. Cortical ROI revealed the most mineralized bone tissue. Conclusions: After 9 months, bone graft resorption was only partially completed and new bone tissue appeared less mineralized in the middle and apical ROI than in the coronal ROI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ESEM-EDX Mineralization and Morphological Analysis of Human Retrieved Maxillary Sinus Bone Graft Biopsies before Loading

Imai

Prati

Zamparini

et al. 2023

JFB

Self Cite

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“…The second clinical study evaluated the effect on implant osseointegration on a collagen membrane subjacent the sinus mucosa [ 53 ]. Twenty patients participated in this randomized clinical trial.…”

Section: A Synopsis Of the Special-editions Papersmentioning

confidence: 99%

Clinical and Histological Healing after Maxillary Sinus Floor Elevation

Botticelli¹

2022

Dentistry Journal

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Sinus floor elevation is a surgical procedure that allows for the insertion of the implant in the posterior region of the maxilla in case of insufficient volume of native bone. Several studies have reported a high success rate, and this has helped to spread this surgical procedure around the world. The subject has been extensively studied and this could lead researchers to think that no new scientific evidence can be provided. However, new ideas and discoveries show that research never reaches a conclusion, and that new information can be added all the time. This collection aimed to provide new evidence that could be added to daily clinical work and to provide new ideas for future research.

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Healing Patterns of Non-Collagenated Bovine and Collagenated Porcine Xenografts Used for Sinus Floor Elevation: A Histological Study in Rabbits

Miyauchi

Izutani

Teranishi

et al. 2022

JFB

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Objective: To compare healing of collagenated and non-collagenated xenografts used for maxillary sinus floor elevation. Materials and Methods: Two different xenografts were used: deproteinized bovine bone (DBBM group) and collagenated corticocancellous porcine bone (collagenated group). Healing was studied after 2, 4, and 8 weeks. The loss of dimensions of the elevated area and the percentages of new bone, xenograft remnants, osteoclastic zones, vessels, inflammatory infiltrates, and soft tissues were analyzed. Three regions were evaluated: close to the bone walls (bone wall region), subjacent the sinus mucosa (submucosa region), and the center of the elevated area (middle region). The primary variables were the percentage of new bone and xenograft remnants. Results: Between 2 and 8 weeks, the elevated areas showed a reduction of 16.3% and 52.2% in the DBBM and collagenated groups, respectively (p < 0.01 between the two areas after 8 weeks). After 8 weeks, the highest content of new bone was observed in the bone wall region, which was higher in the collagenated group than in the DBBM group (41.6% and 28.6%, respectively; p < 0.01). A similar quantity of new bone was found between the two groups in other regions. A higher percentage of vessels in all regions evaluated (p < 0.01) and soft tissue in the sub-mucosa region (p < 0.05) was found in the collagenated group than in the DBBM group. Conclusions: The present study showed that both xenografts allowed new bone formation. In comparison with the non-collagenated xenograft, the collagenated xenograft underwent higher resorption, resulting in greater shrinkage of the elevated space after sinus lifting and a higher content of new bone in the regions close to the bone walls. Clinical relevance: In this study, the region adjacent to the bone wall showed the highest new bone content. This region resembles the base of the sinus, closest to the sinus floor and walls, and is the most important region from a clinical point of view because it is where the implant will be installed. Residues of the biomaterial remained after 8 weeks of healing. Other reports have shown that these biomaterial residues may interfere with the integration of implants.

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Influence on Implant Bone Healing of a Collagen Membrane Placed Subjacent the Sinus Mucosa—A Randomized Clinical Trial on Sinus Floor Elevation

Cited by 4 publications

References 38 publications

ESEM-EDX Mineralization and Morphological Analysis of Human Retrieved Maxillary Sinus Bone Graft Biopsies before Loading

ESEM-EDX Mineralization and Morphological Analysis of Human Retrieved Maxillary Sinus Bone Graft Biopsies before Loading

Clinical and Histological Healing after Maxillary Sinus Floor Elevation

Healing Patterns of Non-Collagenated Bovine and Collagenated Porcine Xenografts Used for Sinus Floor Elevation: A Histological Study in Rabbits

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