Influence on the concentration of drug solution in a venous reservoir by the change of flow rate of a blood pump

Abstract

In this study, the concentration of the drug solution injected into the venous reservoir, which flowed into the patient, was measured in an in vitro model experiment and analyzed based on the law of conservation of mass within the parameters of flow rate using a blood pump. In the experiment, an aqueous KCl solution was injected into a venous reservoir using a syringe pump, and the concentration of potassium ions at the reservoir outlet was measured. The concentration of potassium ions changed according to a first-order lag, almost converging to that at the inlet. The time constant decreased with an increase in the flow rate of the blood pump. The concentration at the reservoir outlet was diluted with a small amount of the injected drug solution.