Influencers of the Decision to Undergo Contralateral Prophylactic Mastectomy among Women with Unilateral Breast Cancer

Raghavendra, Akshara Singareeka; Alameddine, Hala Farouk; Andersen, Clark R.; Selber, Jesse C.; Brewster, Abenaa M.; Barcenas, Carlos H.; Caudle, Abigail S.; Arun, Banu K.; Tripathy, Debu; Ibrahim, Nuhad K.

doi:10.3390/cancers13092050

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…[7] In our study, nearly half of the visible calcifications on second-look US were associated with breast cancer. Given the independent predictive role of clinical manifestation in breast cancer and the strong recommendation for surgery in BI-RADS 5 calcifications, [5] improving the diagnostic accuracy of BI-RADS 4 calcifications without clinical manifestations and other abnormalities on MG could help avoid unnecessary interventional operations. Previous investigations have not revealed a correlation between color flow on second-look US and suspicious calcifications.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that clinical manifestations are significantly associated with breast cancer. [5] Therefore, we sought to investigate whether second-look US can assist in distinguishing BI-RADS 4 calcifications detected on MG without clinical manifestations or other abnormalities.…”

Section: Natural Science Foundation Of Fujian Province Of China (Gran...mentioning

confidence: 99%

“…Previous studies have reported that clinical manifestations are significantly associated with breast cancer. [5]…”

Section: Introductionmentioning

confidence: 99%

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Utility of Second-look Ultrasonography in Distinguishing BI-RADS 4 Calcifications Detected on Mammography: An observational study

Cheng,

Zhu,

Lin

et al. 2024

Medicine

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This study aimed to assess the utility of second-look ultrasonography (US) in differentiating breast imaging reporting and data system (BI-RADS) 4 calcifications initially detected on mammography (MG). BI-RADS 4 calcifications have a wide range of positive predictive values. We hypothesized that second-look US would help distinguish BI-RADS 4 calcifications without clinical manifestations and other abnormalities on MG. This study included 1622 pure BI-RADS 4 calcifications in 1510 women (112 patients with bilateral calcifications). The cases were randomly divided into training (85%) and testing (15%) datasets. Two nomograms were developed to differentiate BI-RADS 4 calcifications in the training dataset: the MG-US nomogram, based on multifactorial logistic regression and incorporated clinical information, MG, and second-look US characteristics, and the MG nomogram, based on clinical information and mammographic characteristics. Calibration of the MG-US nomogram was performed using calibration curves. The discriminative ability and clinical utility of both nomograms were compared using the area under the receiver operating characteristic curve (AUC) and the decision analysis curve (DCA) in the test dataset. The clinical information and imaging characteristics were comparable between the training and test datasets. The bias-corrected calibration curves of the MG-US nomogram closely approximate the ideal line for both datasets. In the test dataset, the MG-US nomogram exhibited a higher AUC than the MG nomogram (0.899 vs 0.852, P = .01). DCA demonstrated the superiority of the MG-US nomogram over the MG nomogram. Second-look US features, including ultrasonic calcifications, lesions, and moderate or marked color flow, were valuable for distinguishing BI-RADS 4 calcifications without clinical manifestations and other abnormalities on MG.

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Section: Discussionmentioning

confidence: 99%

Section: Natural Science Foundation Of Fujian Province Of China (Gran...mentioning

confidence: 99%