Influences of central gray matter stimulation on thalamic neuron responses to high- and low-threshold stimulation of trigeminal nerve structures

Gura, E. V.; Garkavenko, V. V.; Limansky, Yu. P.

doi:10.1016/0306-4522(91)90359-v

Cited by 20 publications

(9 citation statements)

References 39 publications

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“…They also demonstrated that PVG stimulation had a profound inhibitory effect on spontaneous activity in VPL and VPM, which outlasted the stimulation for 20-30 min. Furthermore, stimulation of PVG reduced neuronal activity in CL, CM, Pf, and MD in the cat [68]. The effect of stimulation of structures involved in pain processing on the intralaminar nuclei CM and Pf demonstrates that the latter have a rich connectivity to other pain-encoding structures.…”

Section: Cm-pf Complex and Pain Processing -Development Of Conceptsmentioning

confidence: 95%

“…They also recognized inhibition of Pf neurons by stimulation of the somatosensory nuclei in a stimulation-paradigm-dependent manner. Gura et al [68] compared the responses of thalamic neurons in the intralaminar nuclei (CM, CL, Pf and MD) with the specific sensory relay nucleus (VPM) after teeth pulp stimulation in the cat. Neurons in VPM were found to be more responsive to stimulation of peripheral low-threshold fibers, whereas neurons of the intralaminar nuclei were more responsive to stimulation of high-threshold fibers.…”

Section: Electrophysiological Datamentioning

confidence: 99%

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Center Median-Parafascicular Complex and Pain Control

Weigel

Krauss²

2004

Stereotact Funct Neurosurg

107

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The center median-parafascicular (CM-Pf) complex, which constitutes the major portion of the intralaminar thalamus in man, has long been known to be involved in the processing of pain under normal and pathological conditions. Yet, these ‘forgotten’ nuclei with their rich connectivity to other thalamic nuclei, the basal ganglia and cortical areas have received only relatively little attention over the past two decades. With regard to the recent reinterest in functional stereotactic neurosurgery as a treatment option for chronic refractory pain, the CM-Pf complex has been reconsidered as a target. This review provides a systematic overview on the current knowledge about the anatomy and connectivity of the CM-Pf complex, neurophysiological studies, and on concepts of its role in pain processing under various conditions. We also review the previous experience with ablative surgery and deep brain stimulation of the CM-Pf complex. Studies in men and experimental animals indicate that the CM-Pf complex is part of a medial pain system, which appears to be involved primarily in affective and motivational dimensions of pain. Single-unit recordings from the CM-Pf complex have shown that the activity of CM-Pf cells is modified by painful stimuli. Under pathological conditions, bursting firing patterns and altered discharge rates were found. Thalamotomies targeting at the CM-Pf complex yielded beneficial results for chronic pain, but interpretation of the results is limited. With bifocal deep brain stimulation, short-term effects of CM-Pf stimulation were superior to those of somatosensory thalamic stimulation in neuropathic pain. There is evidence, that the CM-Pf complex might also be involved in the mediation of the beneficial effects of somatosensory thalamic stimulation and periventricular grey stimulation.

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Section: Cm-pf Complex and Pain Processing -Development Of Conceptsmentioning

confidence: 95%

Section: Electrophysiological Datamentioning

confidence: 99%

Center Median-Parafascicular Complex and Pain Control

Weigel

Krauss²

2004

Stereotact Funct Neurosurg

107

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“…Second, since the main long-term effect of preoptic damage on maternal behavior is to interfere with retrieving behavior, it is likely that preoptic efferents to the brain stem ultimately influence neural sites involved in oral and perioral sensorimotor integration. In this regard, it should be pointed out that periaqueductal gray output pathways influence sensory and motor functions within the trigeminal system (29,30).…”

Section: Medial Preoptic Area Output Circuits and Maternal Behaviormentioning

confidence: 99%

A neural circuitry analysis of maternal behavior in the rat

Numan

1994

Acta Paediatrica

109

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Numan M. A neural circuitry analysis of maternal behavior in the rat. Acta Pzdiatr 1994; This article reviews work that shows that the medial preoptic area of the hypothalamus plays a crucial role in controlling the occurrence of maternal behavior in rats. A primary goal of this report is to fit the medial preoptic area into a larger neural circuitry, examining its critical inputs and outputs. Lesions of the medial preoptic area disrupt maternal behavior and estradiol and prolactin injections into this region activate maternal behavior. The medial amygdala, which is located in the limbic telencephalon, sends a neural projection to the preoptic region. Research indicates that this projection influences maternal behavior by relaying olfactory input to the medial preoptic area. The output of the preoptic area influences maternal behavior through descending projections to the brain stem. One of the influences of such projections might be to regulate neural circuits involved in controlling specific maternal responses, such as retrieval (carrying of pups) behavior. Amygdala, brain stem, maternal behavior, medial preoptic area, rats

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“…These procedures suppress the nociceptive stimulation-evoked activity of sensory neurons of the spinal cord and trigeminal nuclei [4][5][6] and of thalamic neurons [7].…”

Section: Introductionmentioning

confidence: 99%

Analgesia Induced by Microwave Irradiation of an Acupuncture Point under Conditions of Visceral Pain in Mice: Role of the Serotonergic Cerebral System

Bagatskaya

Gura

2005

Neurophysiology

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We studied behavioral manifestations of analgesic effects induced in mice by irradiation of the E36 acupuncture point (AcP) by low-intensity microwaves under conditions of visceral pain evoked by i.p. injections of 0.08 ml of a 2% solution of acetic acid. We also examined changes in these analgesic effects resulting from a drop in the level of serotonin after i.p. injection of 300 mg/kg of a blocker of synthesis of serotonin, DL-parachlorophenylalanine (PChPhA). Two modes of irradiation were tested, with a wide frequency range (30 to 300 GHz) and amplitude modulation (mode 1) and with a stable frequency (61 ± ± 4 GHz, mode 2). Irradiation in mode 1 provided a higher level of analgesia than that in mode 2 (decreases in the duration of manifestations of the pain reaction were, on average, 35.7 and 20.4%, respectively). The level of analgesia dropped after injections of PChPhA; the durations of behavioral pain manifestations 24 h after such injections were greater than those in the group with no injections of the blocker by 41.3 and 12.1% in irradiation modes 1 and 2, respectively. The respective figures 48 h after PChPhA injections were 52.0 and 16.1%. Thus, under conditions of visceral pain, irradiation of the AcP by low-intensity microwaves provides noticeable analgesia, and the serotonergic brain system mediates the development of analgesia under the above-mentioned conditions.

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Influences of central gray matter stimulation on thalamic neuron responses to high- and low-threshold stimulation of trigeminal nerve structures

Cited by 20 publications

References 39 publications

Center Median-Parafascicular Complex and Pain Control

Center Median-Parafascicular Complex and Pain Control

A neural circuitry analysis of maternal behavior in the rat

Analgesia Induced by Microwave Irradiation of an Acupuncture Point under Conditions of Visceral Pain in Mice: Role of the Serotonergic Cerebral System

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