Influences of changes in calcium concentration and verapamil on the cardiac depressant effect of ethanol in cat papillary muscle

Martínez, José Luis; Penna, Mario

doi:10.1016/0306-3623(92)90285-r

Cited by 8 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our experiments, acute verapamil(2 pM) exposure alone did not reduce PTD, as occurred in cat ventricular muscle at a lower concentration of verapamil (Martinez and Penna 1992). This finding suggests that rat myocardium may be less sensitive to the NIE of verapmil.…”

Section: Discussionmentioning

confidence: 48%

“…Acute effects of verapamil(2 pM) on baseline mechanical parameters and the inotropic response to ethanol were induced by adding the drug to the superfusate. The dose and concentration of verapamil used in chronic and acute studies have been previously demonstrated to be effective in blocking calcium channels without adversely compromising mechanical hnction (Lonsberry et al 1992;Martinez and Penna 1992;Afzal et al 11988).…”

Section: Experimental Modelmentioning

confidence: 97%

See 1 more Smart Citation

Chronic verapamil treatment attenuates the negative inotropic effect of ethanol in diabetic rat myocardium

Brown¹,

Bhasin²,

Savage³

et al. 1994

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

It is well established that cardiomyopathy is a consistent feature of diabetic myocardium and that alcohol consumption increases the risk of cardiovascular disease among diabetic subjects. The objective of this investigation was to determine whether acute or chronic verapamil treatment attenuates the negative inotropic effect of ethanol (EtOH) in the diabetic rat heart. Wistar rats were made diabetic with streptozotocin (55 mg/kg, iv). Left-ventricular papillary muscles, from normal and diabetic (8 weeks) rats, were superfused with Tyrode's solution at 30 degrees C while driven at 0.5 Hz. A subgroup of diabetic and normal animals received daily injections of verapamil (8 mg/kg, ip; 8 weeks), whereas muscles from untreated animals were exposed to verapamil (2 microM) in vitro. Peak tension developed (PTD), time to peak tension (TPT), time to 90% relaxation (RT90), and the maximum velocities of tension development (+VT) and decay (-VT) were determined in the absence and presence of clinically relevant concentrations of EtOH (80-240 mg/dL, i.e., 17.4-52.1 mM). Ethanol at 80 mg/dL reduced PTD, +VT, and -VT only in preparations from diabetic animals. Higher concentrations of EtOH (120-240 mg/dL) decreased PTD, TPT, +VT, and -VT. The negative inotropic effect of EtOH (240 mg/dL) was attenuated only in diabetic myocardium chronically treated with verapamil, whereas acute verapamil treatment potentiated the negative inotropic effect of EtOH in both normal and diabetic myocardium. Thus, chronic verapamil therapy diminishes the negative inotropic effect of EtOH in diabetic myocardium and acute verapamil treatment exaggerates it.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 48%

Section: Experimental Modelmentioning

confidence: 97%

Chronic verapamil treatment attenuates the negative inotropic effect of ethanol in diabetic rat myocardium

Brown¹,

Bhasin²,

Savage³

et al. 1994

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Son muchos los estudios que se han realizado con personas que abusan del alcohol y su tendencia al suicidio, no habiéndose establecido claramente cuales con las tasas exactas, las cuales dependen del lugar geográfico en donde se ha realizado el estudio, planteándose en cada caso justificaciones basadas en diversos factores (11)(12)(13)(14)(15)(16)(17). Quizás seria interesante pensar en la búsqueda de un mecanismo que explique esta causa de relación en el efecto depresor cardiovascular que produce tanto el etanol (alcohol para consumo humano) (18), como también el efecto depresor de su principal metabolito, el acetaldehído (19), ambos estudios realizados en animales demostraron fuerte efecto depresor cardiaco, pero que podrían extrapolarse a la especie humana.…”

Section: Introductionunclassified

Suicidio: Revisión De Aspectos Neurobiológicos

Echeverry-Quintero

Aristizabal

Barraza

et al. 2021

Rev. Invest. Univ. Quindío

View full text Add to dashboard Cite

Revisión bibliográfica en la que se enfoca el tema del suicidio en la búsqueda de las bases neurobiológicas que traten de dar una explicación sobre las razones mediante las cuales los individuos llegan a esta situación extrema, queesatentarcontrasupropiavida.Losprincipalesfundamentosvandesdeelefectodelalcohol,larelaciónconel colesterol y los receptores de serotonina y en años recientes se ha tratado de identificar un factor genético para poder justificar este problema de salud que está afectando principalmente a los países latinoamericanos, en mujeres que buscan una solución a sus problemas, en una población adolescente (entre 15 a 24 años) con mayor vulnerabilidad y también en los hombres mayores debido a desempleo y divorcio. Necesitándose en la actualidad de la participación de un equipo multidisciplinario para tratar este problema de salud publica cada vez en aumento.

show abstract