Influences of different Fe sources on Fe bioavailability and homeostasis in SD rats

Abstract

The purpose of this study was to determine whether the enteric coating process affects growth performance, Fe bioavailability, and gene expression levels that maintain iron balance in the body. The test was divided into the control group, ferrous sulfate group, ferrous fumarate group, ferrous glycine chelate(1:1) (Fe‐Gly(1:1)) group, ferrous glycine chelate(2:1) (Fe‐Gly(2:1)) group, enteric‐coated Fe‐Gly(1:1) group, and enteric‐coated Fe‐Gly(2:1) group. The results showed that the growth performance of the rats in each iron supplement group was no significant difference among them. The results of serum biochemical indicators showed that the antioxidant capacity of the rats in the iron supplement group after enteric coating increased. The iron supplementation effect of Fe‐Gly(1:1) and Fe‐Gly(2:1) was better than that of ferrous sulfate, and the effect of Fe‐Gly(1:1) after enteric coating was enhanced. The expression levels of IRP1 and IRP2 in the genes of enteric‐coated Fe‐Gly(1:1) and enteric‐coated Fe‐Gly(2:1) were significantly higher than those of ferrous sulfate. The expression levels of IRP1 and IRP2 in the protein of enteric‐coated Fe‐Gly(1:1) group were significantly higher than those in the Fe‐Gly(1:1) group. The above results show that Fe‐Gly can improve the bioavailability and antioxidant capacity of iron and reduce the iron output of feces after enteric coating.