Influences of Feeding Oysters on the Metabolism of Serotonin in Alloxan-Diabetic Rats

Y, Shibata; Hattori, Mitsuo; Takeuchi, Fumika; Otsuka, Hiroyuki; Tsubouchi, Ryoko; Ugata, M.; Shiraishi, Shuichi; Ohta, Toshiyuki; Sugino, Nobuhiro; Sotokawa, Yumiko; Takahashi, Rie; Kotake, Yahito

doi:10.1515/9783110854657-026

Progress in Tryptophan and Serotonin Research 1986 1987

DOI: 10.1515/9783110854657-026

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Influences of Feeding Oysters on the Metabolism of Serotonin in Alloxan-Diabetic Rats

Shibata Y¹,

Mitsuo Hattori²,

Fumika Takeuchi³

et al.

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2015

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“…In addition to these organisms, the consumption of defatted oyster meat exerts hypolipidemic activity as well, and this effect can be ascribed to both the lipid and non-lipid fractions [11]. Chronic feeding of oyster improves glucose tolerance in alloxan-induced diabetic rats [12].…”

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Crassaostrea gigas Oyster Shell Extract Inhibits Lipogenesis via Suppression of Serine Palmitoyltransferase

Tran

Kwon

Kang

et al. 2015

Natural Product Communications

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Oysters are widely consumed seafood, but their shells impose a serious environmental problem. To extend the utilization of oyster shell waste, we investigated the biological role of oyster shell extract. In this study, we verified that the ethanol extract of oyster shell (EOS) contains taurine and betaine, the major components of oyster body. EOS downregulated transcription of Sptlc1 and Sptlc2 mRNA, the subunits of serine palmitoyltransferase (SPT). Suppression of SPT subunits reduced sphinganine and sphingomyelin by inhibiting de novo sphingolipid biosynthesis. Inhibition of sphingomyelin biosynthesis resulted in downregulation of lipogenic gene expression such as ACC, FAS, SCD1, and DGAT2. Consistent with inhibition of lipogenesis, cellular triglyceride levels were diminished by EOS, but cholesterol levels were not altered. Taken together, these results suggest that EOS has a lipid-lowering effect and could be applied as either a therapeutic or preventive measure for metabolic dysfunction.

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mentioning

confidence: 99%

Crassaostrea gigas Oyster Shell Extract Inhibits Lipogenesis via Suppression of Serine Palmitoyltransferase

Tran

Kwon

Kang

et al. 2015

Natural Product Communications

View full text Add to dashboard Cite

show abstract

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Influences of Feeding Oysters on the Metabolism of Serotonin in Alloxan-Diabetic Rats

Cited by 1 publication

References 0 publications

Crassaostrea gigas Oyster Shell Extract Inhibits Lipogenesis via Suppression of Serine Palmitoyltransferase

Crassaostrea gigas Oyster Shell Extract Inhibits Lipogenesis via Suppression of Serine Palmitoyltransferase

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