2014
DOI: 10.7860/jcdr/2014/10770.5319
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Influences of Gender on Postoperative Morphine Consumption

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Cited by 13 publications
(12 citation statements)
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“…Other studies have found that patients with higher socioeconomic status (measured in education level), female gender, mood disorders and those taking sedating medications have an increased risk of opioid OD outside the hospital 15, 16 . Interestingly, Periasamy et al found that male gender was associated with significantly higher consumption of morphine after abdominal operations 17 , which contrasts our findings that men are at lower risk of postoperative OD. Perhaps the risk of postoperative OD in these subgroups is due to use of standard dosing for all patients, not considering medication interactions or difference in weight that might be present.…”
Section: Discussioncontrasting
confidence: 99%
“…Other studies have found that patients with higher socioeconomic status (measured in education level), female gender, mood disorders and those taking sedating medications have an increased risk of opioid OD outside the hospital 15, 16 . Interestingly, Periasamy et al found that male gender was associated with significantly higher consumption of morphine after abdominal operations 17 , which contrasts our findings that men are at lower risk of postoperative OD. Perhaps the risk of postoperative OD in these subgroups is due to use of standard dosing for all patients, not considering medication interactions or difference in weight that might be present.…”
Section: Discussioncontrasting
confidence: 99%
“…In a large recent study investigating visceral postoperative pain after elective abdominal surgery including 450 patients, men required significantly more morphine than women in the first 24 h after surgery (34.4 AE 6.7 vs. 26.8 AE 7.1 mg, P < 0.001) [11]. However, these doses are not weight-based; furthermore, women scored higher pain ratings in this study indicating not a gender difference in pain per se but in analgesic requests with women getting less opioids, and therefore experiencing more pain than men.…”
Section: Visceral and Thoracic Surgerymentioning
confidence: 92%
“…In adults, current evidence suggests that several factors may influence analgesic response during the course of the illness [ 7 ]. For example, it has been reported that men require more morphine in the postoperative period than women [ 8 ] and obesity may partly explain inter-individual variations in opioid efficacy and toxicity [ 9 ]. Moreover, it is fundamental to consider the influence of genetic factors regulating opioid pharmacokinetics (e.g.…”
Section: Introductionmentioning
confidence: 99%