Influences of Genetic Variability and Maternal Factors on Fetal Growth in White-Tailed Deer

Cothran, E. Gus; Chesser, Ronald K.; Smith, Michael H.; Johns, Paul E.

doi:10.2307/2408337

Cited by 30 publications

(30 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Population subdivision will generate heterozygote deficiencies through the Wahlund effect, and although such deficiencies were not recorded by Cothran et aL, deficiencies have been recorded in some of the species exhibiting positive correlations, such as Crassostrea gigas (Singh and Zouros, 1978) and Mytilus edulis (Koehn and Gaffney, 1984). However, it should be pointed out that such deficiencies are not necessarily the result of population structure, and that several species showing positive correlations do not show deviations from Hardy-Weinberg expectations (e.g., Odocoileus virginianus, Cothran et aL, 1983; Mulinia lateralis, Garton et aL, 1984;Pinus rigida, Ledig et aL, 1983).…”

Section: Discussionmentioning

confidence: 93%

“…Since, in man at least, birth weight is more dependent on maternal genotype and maternal environment than on foetal genotype (which contributes about 24 per cent of birth weight variance, Robson, 1978), it is likely to be a poor character to use in man (and probably other mammals) in searches for heterozygosity/growth rate correlations. Notwithstanding, Cothran et aL (1983) for deer and Bottini et a!. (1979) for man have reported such associations, although a study by failed to confirm the results of Bottini et aL Under stabilising selection, and if increasing heterozygosity confers increasing fitness, one might expect individuals of intermediate growth rate to be highly heterozygous.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Growth rate and heterozygosity in the plaice, Pleuronectes platessa

1986

View full text Add to dashboard Cite

Samples of young plaice were examined to see if there was any relationship between growth rate and individual heterozygosity, screened across five polymorphic enzyme loci (Pgm-1, Ada, Mdh-2, Pgi-2, aGpdh-1). Two out of 46 samples showed a significant negative correlation between growth rate and multi-locus heterozygosity; none showed a significant positive correlation. There was no overall tendency to negative or positive correlations. The largest sample (N = 689) showed no relationship between multi-locus heterozygosity and growth rate, although one of the five loci, aGpdh-1, showed a significant positive correlation. The only significant correlation in the next largest sample (N = 248) was between multi-locus heterozygosity and growth rate, and that was negative. Fish of intermediate growth rate were not significantly different in heterozygosity from faster or slower growing fish. There was no relationship between variability in growth rate and multi-locus heterozygosity. These findings are discussed in the context of similar surveys from other species, and the conclusion drawn that the universality of a positive relationship between growth rate and multi-locus heterozygosity remains to be established.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Growth rate and heterozygosity in the plaice, Pleuronectes platessa

1986

View full text Add to dashboard Cite

show abstract

“…Theoretical studies have shown that heterozygosity is heritable when allele frequencies are unequal (Borgia, 1979;Mitton et al, 1993;Neff and Pitcher, 2008), and a number of empirical studies have reported parent-offspring correlations in heterozygosity itself (Cothran et al, 1983;Mitton et al, 1993;Richardson et al, 2004;Hoffman et al, 2007;García-Navas et al, 2009;Oh, 2009;Thoß, 2010;Thonhauser et al, 2014), or inferred them from a parent-offspring correlation in inbreeding coefficients (Reid et al, 2006). Although the presence of substantial heritability of heterozygosity has been formally shown for two-allelic loci more than two decades ago (Mitton et al, 1993), this is not well known among evolutionary biologists (e.g., Coulson and Clegg, 2014).…”

Section: Introductionmentioning

confidence: 99%

Genetic variance components and heritability of multiallelic heterozygosity under inbreeding

2015

View full text Add to dashboard Cite

The maintenance of genetic diversity in fitness-related traits remains a central topic in evolutionary biology, for example, in the context of sexual selection for genetic benefits. Among the solutions that have been proposed is directional sexual selection for heterozygosity. The importance of such selection is highly debated. However, a critical evaluation requires knowledge of the heritability of heterozygosity, a quantity that is rarely estimated in this context, and often assumed to be zero. This is at least partly the result of the lack of a general framework that allows for its quantitative prediction in small and inbred populations, which are the focus of most empirical studies. Moreover, while current predictors are applicable only to biallelic loci, fitnessrelevant loci are often multiallelic, as are the neutral markers typically used to estimate genome-wide heterozygosity. To this end, we first review previous, but little-known, work showing that under most circumstances, heterozygosity at biallelic loci and in the absence of inbreeding is heritable. We then derive the heritability of heterozygosity and the underlying variances for multiple alleles and any inbreeding level. We also show that heterozygosity at multiallelic loci can be highly heritable when allele frequencies are unequal, and that this heritability is reduced by inbreeding. Our quantitative genetic framework can provide new insights into the evolutionary dynamics of heterozygosity in inbred and outbred populations.

show abstract

“…Selection has been shown to occur at the Sordh or a closely linked locus in whitetails . In addition, in white-tailed deer H is correlated with antler characteristics Scribner et a!., 1984), testis size in fawns (Urbston, 1976), body size and fat levels in adult females (Cothran et a!., 1983), rates of fetal development (Cothran et a!., 1983;Chesser and Smith, in press), and fetal number Chesser and Smith, in press). These phenotypic correlates of_heterozygosity do not prove selection for high H, but indirectly suggest the importance of the association of heterozygosity levels and fitness in white-tailed deer as seems to be the case for a variety of organisms (Mitton and Grant, 1984).…”

Section: Srpmentioning

confidence: 99%

Genetic variability in white-tailed deer

et al. 1988

Heredity

View full text Add to dashboard Cite

Genetic variability at 36 loci was studied in white-tailed deer (Odocoileus virginianus) populations, on the Savannah River Plant (SRP) in South Carolina. Mean multilocus heterozygosity (H), percentage of polymorphic loci (P) and average number of alleles per locus (A) for white-tailed deer were calculated and compared with values for white-tailed deer from several locations (SRP deer: H =99 per cent, P005 = 30.6 per cent, A = 1 89; white-tailed deer overall: H = 10•4 per cent, P0.05 = 32.3 per cent, A = 1.94). Frequency distributions for single locus heterozygosity values (h) and the number of alleles per locus for white-tailed deer were found to be significantly different from those of mammals in general. Analysis of single-locus data based on quaternary structure and functional groups of proteins failed to demonstrate expected differences as predicted from the literature. White-tailed deer have a high level of heterozygosity, but they do not exhibit many of the life history and environmental characteristics associated with high heterozygosity in other animals.

show abstract

Influences of Genetic Variability and Maternal Factors on Fetal Growth in White-Tailed Deer

Cited by 30 publications

References 11 publications

Growth rate and heterozygosity in the plaice, Pleuronectes platessa

Growth rate and heterozygosity in the plaice, Pleuronectes platessa

Genetic variance components and heritability of multiallelic heterozygosity under inbreeding

Genetic variability in white-tailed deer

Contact Info

Product

Resources

About