Influences of Helicobacter pylori on serum pepsinogen concentrations in dialysis patients

Abstract

We conclude that H. pylori status should be taken into account when serum pepsinogen concentrations are evaluated in dialysis patients.

The Effects of Continuous Ambulatory Peritoneal Dialysis and Hemodialysis on Serum Pepsinogen Concentrations in Patients with Chronic Renal Failure

“…Our findings are in agreement with the previous reports, showing that serum PG I levels are increased in CRF and HD patients (Nakahama et al 1995;Araki et al 1999;Tamura et al 1999). In contrast, different results have been reported on the serum PG II levels in CRF and HD patients (Nakahama et al 1995;Araki et al 1999;Tamura et al 1999); the serum PG II levels were increased in patients treated by HD (Nakahama et al 1995;Tamura et al 1999), whereas the PG II levels did not change in patients treated by HD (Araki et al 1999).…”

“…In contrast, different results have been reported on the serum PG II levels in CRF and HD patients (Nakahama et al 1995;Araki et al 1999;Tamura et al 1999); the serum PG II levels were increased in patients treated by HD (Nakahama et al 1995;Tamura et al 1999), whereas the PG II levels did not change in patients treated by HD (Araki et al 1999). The present study favors the latter observations.…”

“…Thus, the serum PG levels increase in patients whose renal functions are impaired. In previous studies, it was shown that serum PG levels increase proportionally with the increase in the creatinine levels and this increase also exists in patients treated by HD (Swamy et al 1981;Paimela et al 1985;Nakahama et al 1995;Araki et al 1999;Tamura et al 1999). There are no adequate data about the effect of CAPD, used as a renal replacement treatment in CRF, on serum PG levels.…”

“…Nakahama et al (1995) reported that 21 CAPD patients had a significant increase in the serum PG I and PG II levels compared to the control subjects. Tamura et al (1999) analyzed eight CAPD patients, but these patients had been treated by CAPD for a long time. Moreover, the serum PG levels of the patients before CAPD treatment were unknown in these previous studies.…”

“…Contradictory results are available from the studies examining the effect of dialysis on PG levels (Swamy et al 1981;Nakahama et al 1995;Araki et al 1999;Tamura et al 1999). The main reasons for this confusion include a small number of patients, different renal replacement therapies used, and different stages of renal failure.…”