2006
DOI: 10.1021/ma052419l
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Influences of Intramolecular Cyclization on Structure and Cross-Linking Reaction Processes of PVA Hydrogels

Abstract: Poly(vinyl alcohol) (PVA) hydrogels were prepared in aqueous solutions at different concentrations using glutaraldehyde (GA) as cross-linker. The gel fraction, increase rate of gels, critical gel point, and swelling ratio were measured. Furthermore, the influences of intramolecular cyclization on the cross-linking processes and the structure of formed hydrogels were studied. The results show that the degree of intramolecular cyclization and the ratio of [-CHO]/[-OH] at critical gel point (r c ) increase with t… Show more

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Cited by 34 publications
(22 citation statements)
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“…To obtain the network, chemical cross-linking (Denizli, Can, Rzaev, & Guner, 2004;Kiritoshi & Ishihara, 2004;Molina, Gomez-Anton, & Pierola, 2007;Zhao, Liao, Gao, & Liu, 2006), physical entanglement (Saito, Sakurai, Sakakibara, & Saga, 2003), ionic bonds (de la Torre, Torrado, & Torrado, 2003;Kang, Park, Lee, & Son, 2007;Masci, Husu, Murtas, Piozzi, & Crescenzi, 2003;Wong, Díez-Pascual, & Richtering, 2009) and hydrogen bonds (Jin, Liu, Zhang, Chen, & Niu, 2006) are used in the preparation of hydrogels. Polymer hydrogels have been widely utilized as drug delivery, food, cosmetics, high water-absorbing resin, contact lenses, corneal, implant, substitutes for skin, tendons, ligaments, cartilage, and bone, because of their excellent hydrophilicity, permeability, compatibility and low coefficient of friction (Calvert, 2009;Chang, Duan, Cai, & Zhang 2010;Chan, Whitney, & Neufeld, 2009;Liu & Fan, 2005;Yamamoto, Takahashi, & Tabata, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…To obtain the network, chemical cross-linking (Denizli, Can, Rzaev, & Guner, 2004;Kiritoshi & Ishihara, 2004;Molina, Gomez-Anton, & Pierola, 2007;Zhao, Liao, Gao, & Liu, 2006), physical entanglement (Saito, Sakurai, Sakakibara, & Saga, 2003), ionic bonds (de la Torre, Torrado, & Torrado, 2003;Kang, Park, Lee, & Son, 2007;Masci, Husu, Murtas, Piozzi, & Crescenzi, 2003;Wong, Díez-Pascual, & Richtering, 2009) and hydrogen bonds (Jin, Liu, Zhang, Chen, & Niu, 2006) are used in the preparation of hydrogels. Polymer hydrogels have been widely utilized as drug delivery, food, cosmetics, high water-absorbing resin, contact lenses, corneal, implant, substitutes for skin, tendons, ligaments, cartilage, and bone, because of their excellent hydrophilicity, permeability, compatibility and low coefficient of friction (Calvert, 2009;Chang, Duan, Cai, & Zhang 2010;Chan, Whitney, & Neufeld, 2009;Liu & Fan, 2005;Yamamoto, Takahashi, & Tabata, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Polymer hydrogels, as a sort of unique soft materials, have attracted more and more attention because of their academic importance and special applications 1, 2. The approaches constructing hydrogels were actualized by covalently cross‐linking2, 3 (chemical hydrogels) or specially physical interactions2, 4 (physical hydrogels) of water‐soluble polymer backbone. However, two critical defects restrict their applications: weak mechanical strength and the lack of reforming capability.…”
Section: Introductionmentioning
confidence: 99%
“…The G ′ of pure PVA is high at 12,900 Pa. With the addition of HA, the G ′ is lower by an order of magnitude, and varies from 894 to 1940 Pa. For PVAHA 26, the G ′ was found to be very low, since the gel did not form till 20 min. As many of the drug delivery hydrogel systems have G ′ in the range from 500 to 2000 Pa, most of the PVAHA hydrogels investigated in this work can be used for drug delivery applications …”
Section: Resultsmentioning
confidence: 99%