Influences of lead exposure on its accumulation in organs, meat, eggs and bone during laying period of hens

Wang, Shujie; Li, Qiao; Gao, Yanan; Zhou, Zhenlei; Li, Zhen

doi:10.1016/j.psj.2021.101249

Cited by 17 publications

(6 citation statements)

References 56 publications

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“…The quantitative content of lead in the blood reflects the level of load on the body with its compounds, and the distribution of lead in the organs and tissues of animals depends on the intensity of blood circulation and affinity for metal (Kim et al, 2019;Wang et al, 2021). The results of our studies confirm that the determination of delta-aminolevulinic acid in the serum of poultry is necessary for the timely detection and correction of metabolic disorders caused by low doses of xenobiotics.…”

Section: Discussionsupporting

confidence: 63%

Dose-dependent effect of chronic exposure to lead acetate on the dynamics of the content of delta-aminolevulinic acid and essential trace elements in the serum of laying hens

Доценко

Paliy²,

Морозенко

et al. 2021

Regul. Mech. Biosyst.

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One of the most global and dangerous pollutants is considered to be lead, due to its ability to accumulate in living organisms, to be included in the metabolic cycle, to form highly toxic organometallic compounds, not being biodegradable. To study the chronic effects of lead acetate, an experiment was performed on laying hens of Lohmann Brown cross. For research, one control and three experimental groups were formed, 20 chickens in each. Birds of the experimental groups were administered lead acetate daily with compound feed in doses (in terms of metal): Group I – 50 mg/kg of feed, II – 75 mg/kg of feed, III – 150 mg/kg of feed. Access to water was not restricted. The birds of the control group received a complete diet without lead acetate. On the 30th, 90th, 120th days of the experiment and the 20th day after withdrawal of the toxicant (the 140th day of the experiment), we took blood samples from birds for biochemical and toxicological studies. The concentration of delta-aminolevulinic acid (δ-ALA) in the serum of laying hens was determined by reversed-phase high-performance liquid chromatography. Determination of the content of lead in the serum of laying hens was performed by X-ray fluorescence analysis. The concentration of total calcium, inorganic phosphorus, and magnesium in the serum of the laying hens was determined using production kits. We detected the dose-dependent chronic effect of lead acetate on the dynamics of the content of delta-aminolevulinic acid and essential trace elements in the serum of laying hens. The administration of lead acetate into the body of productive poultry for 120 days in doses of 50, 75, and 150 mg/kg with feed did not cause visible clinical signs of poisoning, but caused a violation of porphyrin metabolism, manifested in a reliable increase in the concentration of delta-aminolevulinic acid in serum on the 30th, 90th and 120th days of the experiment. It has been experimentally proven that the administration into the body of laying hens of lead acetate in doses of 50, 75 and 150 mg/kg of feed for 120 days leads to the maximum accumulation of lead in the serum on the 30th, 90th, and 120th days of the experiment. Prolonged administration of lead acetate to laying hens at high concentrations is characterized by a reliable decrease in the content of total calcium, inorganic phosphorus and magnesium in the serum of laying hens and a reliable increase in the content of ferrum. In the future it is necessary to study the intensity of lipid peroxidation processes in laying hens under chronic exposure to lead acetate.

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Section: Discussionsupporting

confidence: 63%

Dose-dependent effect of chronic exposure to lead acetate on the dynamics of the content of delta-aminolevulinic acid and essential trace elements in the serum of laying hens

Доценко

Paliy²,

Морозенко

et al. 2021

Regul. Mech. Biosyst.

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“…The use of fertilizers and pesticides in rice, soybeans and corn can be the source of contamination through Cd-contained feed (Alkhalaf et al, 2010;Corguinha et al, 2015). Cadmium can damage the kidneys and accumulate in bone (Kim et al, 2019;Bortey-Sam et al, 2015;Wang et al, 2021). According to several research findings, there is a significant correlation between the content of heavy metals in feed with that in eggs.…”

Section: Resultsmentioning

confidence: 99%

Lead and Cadmium Residues in Commercial Poultry Eggs in West Java Indonesia

Harlia

Marlina

Hidayati

et al. 2022

JAP

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Anthropogenic contamination of heavy metals in both soil and water threatens human health through the consumption of livestock products. Important heavy metal toxins, namely lead (Pb) and cadmium (Cd) are present in livestock feed and drinking water and detected in poultry meat and eggs. This study aimed to detect Pb and Cd in poultry eggs (local farms, commercial farms, quail, and ducks) that are consumed by humans almost every day and considered a source of pollution in the environment farm. This research was exploratory research using the survey method and the samples were drawn randomly. The data were analyzed descriptively by calculating the mean of the heavy metal content of Pb and Cd in the samples studied and then compared with the Maximum Residue Limit of Pb and Cd recommended by the Food and Drug Supervisory Agency of the Republic of Indonesia No. 5/2018. The results showed that Pb content in poultry eggs exceeded the Maximum Residue Limit, which was 0.2500 mg/kg except for Pb content in duck eggs and Cd content in poultry eggs in which the samples were below the Maximum Residue Limit.

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“…In this current study, the hepatic tissue of the PbAc-exposed group showed a substantial increase in PbAc residues, which was consistent with earlier findings [ 4 , 65 ]. PbAc accumulates largely in the liver and kidneys, because these organs are the primary locations for Pb excretion and contain proteins with a high affinity for PbAc binding, such as metallothionein, acyl-CoA binding protein, and thymosin β4 [ 66 ]. In addition, the group treated with AOFE + PbAc showed a significant decrease in hepatic PbAc concentration.…”

Section: Discussionmentioning

confidence: 99%

Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats

Aminu,

Umar,

Makena

et al. 2023

Environ Anal Health Toxicol

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Lead (Pb) poisoning is an environmental substance that accumulates in the hepato-renal tissue, which is hazardous to health, while Anacardium occidentale L. is a tropical herb used to treat oxidative stress and inflammatory diseases. The aim of this study was to investigate the antagonistic effect of Anacardium occidentale leaf extract on lead acetate exposure-induced hepatorenal toxicity in rats. Thirty-six adult Wistar rats were split into six equal groups (n = 6). Group I served as a control, and groups II and III were administered lead acetate (50 mg/kg) and Anacardium occidentale leaf extract (400 mg/kg), respectively, while rats in groups IV–VI were administered Anacardium occidentale (L) extract (200 mg/kg and 400 mg/kg) and 10 mg/kg of Succimer, respectively, and were then administered lead acetate (50 mg/kg). When compared to the group I, rats administered lead acetate showed an increase in hepatic enzymes, urea, creatinine, MDA, TNF-α, and IL-1β (p < 0.001) levels and decreased levels of SOD, CAT, and GSH, whereas Anacardium occidentale prevented the increase in hepatorenal function parameters, oxidative stress, and inflammatory markers (TNF-α and IL-1β) induced by lead acetate. Rats administered only lead acetate had a marked increase in hepatic Pb concentration, severe hepatic steatosis, and renal glomerulus degeneration. However, treatment with Anacardium occidentale extract and succimer decreases the Pb concentration, oxidative stress, and inflammation, and also reduces histological liver steatosis and glomerular cytoarchitecture deterioration in the kidney. The results of this study revealed that Anacardium occidentale extract protects against lead acetate-induced liver and kidney toxicity by decreasing oxidative stress and inflammation.

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Influences of lead exposure on its accumulation in organs, meat, eggs and bone during laying period of hens

Cited by 17 publications

References 56 publications

Dose-dependent effect of chronic exposure to lead acetate on the dynamics of the content of delta-aminolevulinic acid and essential trace elements in the serum of laying hens

Dose-dependent effect of chronic exposure to lead acetate on the dynamics of the content of delta-aminolevulinic acid and essential trace elements in the serum of laying hens

Lead and Cadmium Residues in Commercial Poultry Eggs in West Java Indonesia

Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats

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