Influences of maternal nutrient restriction and arginine supplementation on visceral metabolism and hypothalamic circuitry of offspring

Prezotto, Ligia D.; Thorson, Jennifer F.; Borowicz, P. P.; Peine, Jena; Bedenbaugh, Michelle N.; Hileman, Stanley M.; Lents, C. A.; Caton, J. S.; Swanson, K. C.

doi:10.1016/j.domaniend.2018.06.001

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…These data indicate that liver energy use was less in offspring from nutrient-restricted dams. Data from Prezotto et al (2014 , 2018 ) described earlier are supported by in vitro oxygen consumption data in fetal calves from cows fed control or restricted and then realimented diets ( Prezotto et al, 2016 ). These authors suggested that both cows and fetal calves during gestation can modulate maintenance energy requirements in response to nutrient restriction and realimentation.…”

Section: Offspring Maintenance Requirementsmentioning

confidence: 72%

“…Decreases in hepatic oxygen consumption in this study likely resulted from changes in liver mass and not because of changes in oxygen use per unit of tissue; however, small intestinal in vitro oxygen consumption was increased per unit of tissue, suggesting altered tissue energy use. In a follow-up study, with mature ewes fed control-intake, restricted-intake (60% of controls), or restricted-intake plus rumen-protected arginine, in vitro oxygen consumption of hepatic and small intestinal tissues were investigated in 54-d-old offspring ( Prezotto et al, 2018 ). Data shown in Table 3 (adapted from Prezotto et al, 2018 ) showed that hepatic but not jejunal oxygen consumption was decreased in lambs from nutrient-restricted dams.…”

Section: Offspring Maintenance Requirementsmentioning

confidence: 99%

“…In a follow-up study, with mature ewes fed control-intake, restricted-intake (60% of controls), or restricted-intake plus rumen-protected arginine, in vitro oxygen consumption of hepatic and small intestinal tissues were investigated in 54-d-old offspring ( Prezotto et al, 2018 ). Data shown in Table 3 (adapted from Prezotto et al, 2018 ) showed that hepatic but not jejunal oxygen consumption was decreased in lambs from nutrient-restricted dams. In fact, hepatic oxygen consumption when expressed per gram of tissue, per whole tissue, or per unit of body weight was decreased in lambs from nutrient-restricted ewes.…”

Section: Offspring Maintenance Requirementsmentioning

confidence: 99%

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Maternal nutrition and programming of offspring energy requirements1

Caton

Crouse

Reynolds

et al. 2019

Translational Animal Science

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Section: Offspring Maintenance Requirementsmentioning

confidence: 72%

Section: Offspring Maintenance Requirementsmentioning

confidence: 99%

Section: Offspring Maintenance Requirementsmentioning

confidence: 99%

See 1 more Smart Citation

Maternal nutrition and programming of offspring energy requirements1

Caton

Crouse

Reynolds

et al. 2019

Translational Animal Science

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“…The fact that fetal liver mass (as a % of BW) was increased in fetuses from LG heifers indicates that the liver grew at a greater rate than that of the overall body during the first 83 d of gestation. Studies investigating fetal hepatic and small intestinal in vitro oxygen consumption in pregnant ewes, cows, and their fetuses [ 40 , 41 , 42 ] have demonstrated that both dams and fetal offspring during gestation can modulate maintenance energy requirements in response to nutrient restriction and realimentation. Even though we did not work with a nutrient restriction model, our treatments were designed to model growth trajectories of grazing heifers receiving or not receiving protein and energy supplement during early gestation.…”

Section: Discussionmentioning

confidence: 99%

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers I: Effects on Dam Hormonal and Metabolic Status, Fetal Tissue and Organ Mass, and Concentration of Glucose and Fructose in Fetal Fluids at d 83 of Gestation

Menezes

McCarthy

Kassetas

et al. 2022

Animals

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Thirty-five crossbred Angus heifers (initial BW = 359.5 ± 7.1 kg) were randomly assigned to a 2 × 2 factorial design to evaluate effects of vitamin and mineral supplementation [VMSUP; supplemented (VTM) vs. unsupplemented (NoVTM)] and different rates of gain [GAIN; low gain (LG), 0.28 kg/d, vs. moderate gain (MG), 0.79 kg/d] during the first 83 d of gestation on dam hormone and metabolic status, fetal tissue and organ mass, and concentration of glucose and fructose in fetal fluids. The VMSUP was initiated 71 to 148 d before artificial insemination (AI), allowing time for mineral status of heifers to be altered in advance of breeding. At AI heifers were assigned their GAIN treatment. Heifers received treatments until the time of ovariohysterectomy (d 83 ± 0.27 after AI). Throughout the experiment, serum samples were collected and analyzed for non-esterified fatty acids (NEFA), progesterone (P4), insulin, and insulin-like growth factor 1 (IGF-1). At ovariohysterectomy, gravid reproductive tracts were collected, measurements were taken, samples of allantoic (ALF) and amniotic (AMF) fluids were collected, and fetuses were dissected. By design, MG had greater ADG compared to LG (0.85 vs. 0.34 ± 0.04 kg/d, respectively; p < 0.01). Concentrations of NEFA were greater for LG than MG (p = 0.04) and were affected by a VMSUP × day interaction (p < 0.01), with greater concentrations for NoVTM on d 83. Insulin was greater for NoVTM than VTM (p = 0.01). A GAIN × day interaction (p < 0.01) was observed for IGF-1, with greater concentrations for MG on d 83. At d 83, P4 concentrations were greater for MG than LG (GAIN × day, p < 0.01), and MG had greater (p < 0.01) corpus luteum weights versus LG. Even though fetal BW was not affected (p ≥ 0.27), MG fetuses had heavier (p = 0.01) femurs than LG, and VTM fetuses had heavier (p = 0.05) livers than those from NoVTM. Additionally, fetal liver as a percentage of BW was greater in fetuses from VTM (P = 0.05; 3.96 ± 0.06% BW) than NoVTM (3.79 ± 0.06% BW), and from LG (p = 0.04; 3.96 ± 0.06% BW) than MG (3.78 ± 0.06% BW). A VMSUP × GAIN interaction was observed for fetal small intestinal weight (p = 0.03), with VTM-MG being heavier than VTM-LG. Therefore, replacement heifer nutrition during early gestation can alter the development of organs that are relevant for future offspring performance. These data imply that compensatory mechanisms are in place in the developing conceptus that can alter the growth rate of key metabolic organs possibly in an attempt to increase or decrease energy utilization.

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“…The ruminant gastrointestinal tract and liver constitute less than 10% of body weight (BW) but account for approximately 50% of total energy expenditure [5] and are major components defining maintenance requirements [6]. Changes in maternal and fetal visceral organ mass in response to nutrient restriction during gestation could potentially alter maintenance energy requirements of both the dam and fetus [7][8][9]. Programming of offspring maintenance energy requirements could be a useful strategy to optimize performance and efficiency in ruminants [10].…”

Section: Introductionmentioning

confidence: 99%

Prenatal and Postnatal Nutrition Influence Pancreatic and Intestinal Carbohydrase Activities of Ruminants

Trotta

Swanson

2021

Animals

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In ruminant livestock species, nutrition can play an important role in the long-term programming of gastrointestinal function. Pancreatic and small intestinal digestive enzymes are important for postruminal digestion of carbohydrates and protein. Carbohydrases have been shown to respond to changes in the level of feed intake and the dietary inclusion of specific nutrients, including arginine, butyrate, folic acid, fructose, and leucine. Understanding how diet influences enzyme development and activity during prenatal and postnatal life could lead to the development of dietary strategies to optimize offspring growth and development to increase digestive efficiency of ruminant livestock species. More research is needed to understand how changes in fetal or neonatal carbohydrase activities in response to nutrition influence long-term growth performance and efficiency in ruminant livestock species to optimize nutritional strategies.

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Influences of maternal nutrient restriction and arginine supplementation on visceral metabolism and hypothalamic circuitry of offspring

Cited by 10 publications

References 33 publications

Maternal nutrition and programming of offspring energy requirements1

Maternal nutrition and programming of offspring energy requirements1

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers I: Effects on Dam Hormonal and Metabolic Status, Fetal Tissue and Organ Mass, and Concentration of Glucose and Fructose in Fetal Fluids at d 83 of Gestation

Prenatal and Postnatal Nutrition Influence Pancreatic and Intestinal Carbohydrase Activities of Ruminants

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