2022
DOI: 10.1155/2022/5926834
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Influences of miR-378a-3p on the Pathogenesis of Allergic Rhinitis via GzmB-Mediated Inflammatory Reaction

Abstract: Background and objective. Allergic rhinitis (AR), a highly frequently seen chronic inflammation of the upper respiratory tract, shows a growing global incidence. The modern research on the pro-inflammatory mechanism molecularly offers a new direction for the early therapy AR in the future and also reveals the potential therapeutic targets of IT, which is known as the breakthrough of diagnosis and therapy of AR. Through the screening of GSE43523 data set in GEO, we discovered aberrant expression of granzyme B (… Show more

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“…Previous research endeavors have made signi cant strides in understanding the impact of certain miRNAs on scar formation and investigating the potential underlying mechanisms [12][13][14][15][16]. The current study is speci cally focused on miR-378a-3p, a miRNA that has been previously implicated in various biological functions and processes such as cell growth, cell cycle regulation, migration, differentiation, metabolism, and angiogenesis [17][18][19][20][21]. Recent investigations have also linked miR-378a to myocardial brosis, liver brosis, and interstitial brosis [22,23].…”
Section: Introductionmentioning
confidence: 99%
“…Previous research endeavors have made signi cant strides in understanding the impact of certain miRNAs on scar formation and investigating the potential underlying mechanisms [12][13][14][15][16]. The current study is speci cally focused on miR-378a-3p, a miRNA that has been previously implicated in various biological functions and processes such as cell growth, cell cycle regulation, migration, differentiation, metabolism, and angiogenesis [17][18][19][20][21]. Recent investigations have also linked miR-378a to myocardial brosis, liver brosis, and interstitial brosis [22,23].…”
Section: Introductionmentioning
confidence: 99%