2020
DOI: 10.1002/lary.29242
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Influences of GABAergic Inhibition in the Dorsal Medulla on Contralateral Swallowing Neurons in Rats

Abstract: Objectives: We aimed to examine the effect of unilateral inhibition of the medullary dorsal swallowing networks on the activities of swallowing-related cranial motor nerves and swallowing interneurons.Methods: In 25 juvenile rats, we recorded bilateral vagal nerve activity (VNA) as well as unilateral phrenic and hypoglossal activity (HNA) during fictive swallowing elicited by electrical stimulation of the superior laryngeal nerve during control and following microinjection of the GABA agonist muscimol into the… Show more

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Cited by 8 publications
(1 citation statement)
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“…An incomplete activation of PiCo activates the muscular components of the swallow, without establishing the coordinated timing and sequence of the pattern. The swallow pattern generators (SPG) are thought to consist of bilateral circuits (hemi-CPGs) that govern ipsilateral motor activities, but receive crossing inputs from contralateral swallow interneurons in the reticular formation, thought to coordinate synchrony of swallow movements (Kinoshita et al, 2021; Sugimoto, Umezaki, Takagi, Narikawa, & Shin, 1998; Sugiyama et al, 2011). It is possible that unilateral stimulation of PiCo either desynchronizes swallow interneurons or activates only one side of the SPG.…”
Section: Discussionmentioning
confidence: 99%
“…An incomplete activation of PiCo activates the muscular components of the swallow, without establishing the coordinated timing and sequence of the pattern. The swallow pattern generators (SPG) are thought to consist of bilateral circuits (hemi-CPGs) that govern ipsilateral motor activities, but receive crossing inputs from contralateral swallow interneurons in the reticular formation, thought to coordinate synchrony of swallow movements (Kinoshita et al, 2021; Sugimoto, Umezaki, Takagi, Narikawa, & Shin, 1998; Sugiyama et al, 2011). It is possible that unilateral stimulation of PiCo either desynchronizes swallow interneurons or activates only one side of the SPG.…”
Section: Discussionmentioning
confidence: 99%