Influences of supra-physiological temperatures on microstructure and mechanical properties of skin tissue

Lin, Min; Zhai, Xiao Liang; Wang, Shuqi; Wang, Zhengjin; Xu, Feng; Lu, Tian Jian

doi:10.1016/j.medengphy.2011.12.003

Cited by 15 publications

(10 citation statements)

References 41 publications

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“…Increases in the size of collagen fibrils by thermal denaturation has been reported in skin and tendons , and the mechanism is thought to be dissociation of the triple helix of collagen molecules . As collagen fibers are abundant in adventitia of renal arteries, thermal denaturation of collagen molecules could have led to the thickening of the entire adventitia in this study.…”

Section: Discussionmentioning

confidence: 57%

Acute changes in histopathology and intravascular imaging after catheter‐based renal denervation in a porcine model

Sakaoka

Takami

Onimura

et al. 2017

Cathet Cardio Intervent

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Section: Discussionmentioning

confidence: 57%

Acute changes in histopathology and intravascular imaging after catheter‐based renal denervation in a porcine model

Sakaoka

Takami

Onimura

et al. 2017

Cathet Cardio Intervent

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“… 1 Application of supra-physiological temperatures (which is typical for antiaging procedures based on application of the radio-frequency currents) was shown to reduce the skin stiffness by about 30% at 45°C and by about 50% at 50°C. 2 These and several other experimental and clinical results clearly refute the assumption that the stand-alone reinforcement of the skin should causally improve the appearance of the aging skin.…”

Section: Introductionmentioning

confidence: 79%

Role of adipose tissue in facial aging

Wollina

Wetzker

Abdel-Naser

et al. 2017

CIA

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Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.

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“…Skin mechanical properties have been usually measured with macroscopic instruments considering the entire skin thickness . Other studies have been attentive to determine the elastic modulus of skin layers by indentation test .…”

Section: Introductionmentioning

confidence: 99%

Atomic force microscopy for biomechanical and structural analysis of human dermis: A complementary tool for medical diagnosis and therapy monitoring

Peñuela

Negro

Massa

et al. 2018

Experimental Dermatology

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Skin mechanical properties are usually measured considering the entire skin thickness and very little is known about the mechanical behaviour of individual skin layers. We propose atomic force microscopy (AFM) as a tool to quantify nanoscale changes in the biomechanical properties and ultrastructure of human papillary dermis exposed to different mechanical and physical stimuli. Samples from 3 human skin biopsies were studied: one stretched by obesity, one subjected to a high level of sun exposure and normal skin as control. Slices of the papillary dermis layer were harvested at controlled depths from each skin biopsy and 25 μm areas of each slice were imaged and D-periodicity of collagen fibres measured by AFM, together with their stiffness. Standard histological analysis was also carried out to correlate biochemical properties and their distribution with stiffness and topography. We obtained similar stiffness values between the sample affected by obesity and the control sample at any depth level into the dermis, while the sun-exposed sample presented a significantly lower stiffness. Additionally, all samples presented an increase in the stiffness at higher depths into the papillary dermis layer. Collagen fibres close to the epidermis of sample affected either by obesity and sun exposure-the former even more than the latter-are thicker and present a larger D-period than those in the control sample. Our results open the possibility to use structural and mechanical analysis based on AFM as a complementary tool for medical diagnosis and therapy monitoring.

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Influences of supra-physiological temperatures on microstructure and mechanical properties of skin tissue

Cited by 15 publications

References 41 publications

Acute changes in histopathology and intravascular imaging after catheter‐based renal denervation in a porcine model

Acute changes in histopathology and intravascular imaging after catheter‐based renal denervation in a porcine model

Role of adipose tissue in facial aging

Atomic force microscopy for biomechanical and structural analysis of human dermis: A complementary tool for medical diagnosis and therapy monitoring

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