The present contribution gives an overview on innovative methods to characterize cyclic deformation and lifetime behavior of metallic materials and hybrid joints based on high precision measurement of electrical resistance, temperature and magnetic properties during fatigue testing. General aim is to minimize the number of fatigue tests for reliable S-N curve calculation. Moreover, instrumented cyclic hardness tests allow short-time assessment of cyclic hardening in case of limited availability of test material. The methods are applied to a wide range of materials, from carbon steels, over cast iron and metastable austenitic steels to ultrasonically welded Al-alloy/polymer matrix composites.