Article InfoSmoking attends to kill one person every six seconds and causing a variety of diseases like cancer and even psychological problems and caused millions of mortalities. The adolescents are the most ages who start smoking due to many psychosocial factors they start smoking in early age causing more harms and addicted to smoking which worsen the psychological disorders. The study aim is to find the psychosocial determinants that cause smoking initiation and to find the relationship between these determinants and the demographic information. The study is a descriptive cross-sectional study applied on the mediatory and secondary smoking students in Al-Rifa`i City from the 1st November 2016 until 11 th Jun 2017 among (8) schools were chosen randomly and by using scales for depression, anxiety, stress and social determinants, and by using simple random sampling (370) smoking students were chosen whose ages were (13-19) years. (370) smoking students whose ages were (13-19) years, (49.5%) of them had been assessed with mild depression, (47.3%) of them had mild anxiety and (46.8%) had a mild stress, in addition to (9) affected social factors. Moreover, there was a significant relationship between the depression and marital status, anxiety and each of marital status, parent social status, economic status, age of beginning of narghile smoking and the continuity of smoking, stress and smoking type and narghile smoking frequency, and the social determinants and the living status The general conclusion is that the psychological determinants (depression, anxiety, stress) and social determinants were affected in smoking initiation among adolescents and some of them having an advance situation of psychological problems. The study recommended working on establishing and improve programs to prevent smoking in schools in addition to working on teaching families and teachers how to deal with the psychological problems of the adolescents to not lose them in smoking way.