Influences on cortisol and noradrenergic turnover of healthy controls and depressed patients during L-tryptophan loading

Maes, Michaël; Vandevelde, Rikka; Suy, E.

doi:10.1016/0165-0327(89)90040-2

Cited by 20 publications

(14 citation statements)

References 44 publications

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“…However, this effect was only significant in melancholic patients (a 50 per cent increase), whereas no effects were observed in minor and simple major depressives. These results corroborate those of our earlier report (Maes et al, 1989) that L-TRP loading (2 g orally) increased UFC excretion by 49 per cent. So, 2 g and 5 g L-TRP appear to exhibit equal enhancing effects on the UFC excretion of melancholic patients.…”

Section: Discussionsupporting

confidence: 95%

“…Some (Modlinger et al, 1979(Modlinger et al, , 1980 but not all authors (Woolf and Lee, 1977) found that L-TRP significantly increased plasma cortisol. Recently, Maes et al (1989) showed that L-TRP loading (2 g orally) resulted in an increased free cortisol (UFC) excretion in 24 h urine of melancholic patients, whereas no effects were established in normal controls, minor and simple major depressives. L-TRP loading was shown to produce an increased central serotonergic metabolism lasting for 1 6 1 8 h (Eccleston et al, 1970).…”

Section: Introductionmentioning

confidence: 98%

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Significantly increased urinary free cortisol excretion in melancholic depressed females during L‐tryptophan loading

Maes¹,

Minner²,

Suy³

et al. 1990

Human Psychopharmacology

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To assess the status of serotonergic neurotransmission in depressed females, the authors examined the excretion of free cortisol in 24 h urine both before and after administering 5 g L-tryptophan (L-TRP) orally. The depressed patients were classified according to the DSM-I11 into minor, simple major and major depression with melancholia. We found a significant, enhancing effect for L-TRP on urinary free cortisol (UFC) excretion. The absolute increments in UFC induced by L-TRP were significantly higher in melancholic females as compared to minor and simple major depressives. We found no differences among the DSM-I11 groups in the availability of L-TRP to the brain, 9 h after L-TRP administration.

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Significantly increased urinary free cortisol excretion in melancholic depressed females during L‐tryptophan loading

Maes¹,

Minner²,

Suy³

et al. 1990

Human Psychopharmacology

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“…The 24 h urinary MHPG levels for the volunteers in this study are within the normal range reported in the literature [ Maes et al, 1989;Muscettola et al, 1984;Lensch et al, 1987;DeMet et al, 1985;Alonso et al, 1981;Dekirmenjian et al, 1970;Karege, 1984;Julien et al, 1988;Giedke et al, 1982;Wehr et al, 1980;Johnston et al, 1983 [ 19781 can be combined to make a direct comparison to the collection intervals in our study. Increases over the 0-4 h interval are more pronounced in our study (4-8 h, 33 vs. 9%; and 8-12 h, 59 vs. 30%) than in…”

Section: Discussionsupporting

confidence: 61%

“…Central noradrenergic and serotonergic systems have been linked to affective disorders, and are often the focus of clinical research into effective drug therapies [Maes et al, 1989;LaPierre, 1982;Kelwala et al, 1983;Maas et al, 19801. A consistent decrease in urinary 3-methoxy-4-hydroxyphenylglycol (M HPG) has been associated with a variety of antidepressant drugs [Veith et al, 1983;Benedetti et al, 1984;Sharma et al, 1990;Liebowitz et al, 19851.…”

Section: Introductionmentioning

confidence: 99%

Effect of a novel monamine oxidase‐a inhibitor, bw 1370U87, on urinary 3‐methoxy‐4‐hydroxyphenylglycol in normal volunteers

Hedeen

White

Cooper

et al. 1993

Drug Development Research

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Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels were measured i n 14 normal volunteers during a Phase I study of the novel, reversible rnonoamine oxidase-A (MAO-A) inhibitor BW 1370U87 targeted for the treatment of depression. Baseline MHPG excretion (day 0)showed a significant diurnal increase (n = 14, P < 0.05) between 1200 and 2000 h. Oral administration of BW 1370U87 produced significant (3545% maximal, P < 0.05) decreases from these basal levels during the same 1200-2000 h time interval. Twenty-four hours after the dose (dose was given at 0800 h), urinary MHPG levels returned to baseline, consistent with a reversible mechanism of inhibition by BW 13701187. Decreases in urinary MHPG did not appear to be dose-dependent between 200-800 mg BW 1370U87 per day, suggesting that maximal MAO-A inhibition was achieved at the 200 mg dose. These effects on MHPG excretion may be helpful in predicting the efficacy of BW 1370U87 in the treatment of depression. o 1993 Wiley-Liss, Inc.

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“…The secretion of several pituitary hormones -e.g. adrenocorticotrophic hormone (ACTH), cortisol, prolac tin, p-endorphin -is partly regulated by serotonergic inputs [Lai and Martin, 1980;Ganong, 1984;Martin and Reichlin, 1987], It was posited that altered responses to a serotonin agonist challenge test during depression could reflect central dysfunctions in one or more steps in sero tonin synthesis, storage, release or receptor function [Meltzer et al, 1984;Maes et al, 1987], Recently, significant increases in ACTH, cortisol and prolactin secretion after loading with L-tryptophan or 5-hydroxytryptophan were detected in major-depressed patients with melancholia [Meltzer et al, 1984;Koyama and Meltzer, 1986;Maes et al, 1987Maes et al, , 1989c. These findings suggest the existence of a supersensitive central serotonergic system in severely depressed patients [Meltzer et al, 1984;Maes et al, 1989d].…”

Section: Introductionmentioning

confidence: 99%

Cortisol, ACTH, Prolactin and Beta-Endorphin Responses to Fenfluramine Administration in Major-Depressed Patients

Maes¹,

Jacobs²,

Suy³

et al. 1989

Neuropsychobiology

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In the past, some researchers found increased cortisol and prolactin responses to the administration of fenfluramine in major-depressed patients. It was believed that the fenfluramine test could prove to constitute another challenge probe to reflect the central serotonergic function. The present study was conducted in order to investigate the pituitary/adrenal responses to fenfluramine in major- versus minor-depressed patients. To this end we administered 60 mg D, L-fenfluramine p.o. to 40 depressed patients categorized according to the DSM-III. The basal levels of cortisol, adrenocorticotrophic hormone (ACTH), β-endorphins and prolactin and their levels 2 and 4 h after fenfluramine administration were measured. We found no significant effect for fenfluramine treatment on cortisol, ACTH or β-endorphins. There was a significant (p = 0.02) effect for fenfluramine treatment on prolactin. The enhanced secretion of prolactin was only significant (p = 0.006) in major (296.X2, 296.X3, 296.X4) and not in minor (300.40, 309.00) depressives. It was concluded that our findings corroborate the thesis of a hypersensitive serotonergic neurotransmission during a major depressive episode.

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Influences on cortisol and noradrenergic turnover of healthy controls and depressed patients during L-tryptophan loading

Cited by 20 publications

References 44 publications

Significantly increased urinary free cortisol excretion in melancholic depressed females during L‐tryptophan loading

Significantly increased urinary free cortisol excretion in melancholic depressed females during L‐tryptophan loading

Effect of a novel monamine oxidase‐a inhibitor, bw 1370U87, on urinary 3‐methoxy‐4‐hydroxyphenylglycol in normal volunteers

Cortisol, ACTH, Prolactin and Beta-Endorphin Responses to Fenfluramine Administration in Major-Depressed Patients

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