Due to the low permeability and apparent mechanical anisotropy of shale reservoirs, shale oil production highly depends on the performance of hydraulic fracturing of the tight reservoir. Pre-injection of CO 2 before hydraulic fracturing treatment has been proven beneficial to enhance shale oil production. A comprehensive understanding of the effect of changes in the properties of shale reservoirs after preinjected CO 2 on the hydraulic fracturing behavior of shale reservoirs is essential to improve the stimulated reservoir volume (SRV) of shale oil reservoirs. In this study, comprehensive evaluating parameters were proposed to specify the variation of mechanical properties of shale rock at different soaking times of CO 2 based on published testing parameters of shale. Accordingly, a threedimensional (3D) numerical model was established and three groups of horizontal well fracturing cases with different cluster spacings were conducted based on the adaptive FE−DE method to simulate and compare the hydraulic fracturing behavior in the reservoirs with different mechanical properties. We established a quantitative relationship between the alterations in reservoir properties and the stimulated reservoir volume. The results indicate that both the brittleness and conductivity properties of shale rock are dramatically improved as the increment of soaking time of CO 2 . It is beneficial to improve the SRV, and the initiation pressure is reduced with the increment of soaking time of CO 2 . However, as the stress shadow effect is involved in the horizontal well fracturing, the complexity of the hydrofracturing crack is significantly enhanced to restrain the development of hydrofracturing crack. When the cluster spacing is larger, the stress shadow effect is weakened, and the weakening effect of CO 2 soaking on reservoir is more obvious.