1997
DOI: 10.1590/s0037-86821997000200002
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Influência de corticóide, na doença de Chagas crônica, administrado em virtude de afecções associadas

Abstract: O comportamento da infecção humana pelo Trypanosoma cruzi quando vigente imunodeficiência ainda requer melhores esclarecimentos. Essa necessidade está ficando cada vez mais imperiosa porque a concomitância de doença de Chagas e afecções nas quais o distúrbio imunitário existe é atualmente mais comum e, também, em virtude do maior u s o a t u a l d e f á r m a c o s q u e o r i g i n a m a imunodepressão 2 9 10 . Além disso, a crescente realização de transplantes de órgãos, sendo preciso coibir rejeições, en… Show more

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Cited by 23 publications
(10 citation statements)
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“…Interestingly, the epithelial midgut alteration is correlated with parasite death, indicating that the epithelial extracellular membranes are involved in the establishment and development of T. cruzi in the gut of this vector [38]. The beneficial effect of steroids on T. cruzi has been shown in the chronic stage of Chagas disease in humans [39]. In addition, T. cruzi itself is able to produce androgens and estrogens when incubated in the presence of steroid precursors, which suggests the presence of active parasite steroidogenic enzymes and increases the significance of the observation of steroid metabolites in triatomine feces [40], [41].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the epithelial midgut alteration is correlated with parasite death, indicating that the epithelial extracellular membranes are involved in the establishment and development of T. cruzi in the gut of this vector [38]. The beneficial effect of steroids on T. cruzi has been shown in the chronic stage of Chagas disease in humans [39]. In addition, T. cruzi itself is able to produce androgens and estrogens when incubated in the presence of steroid precursors, which suggests the presence of active parasite steroidogenic enzymes and increases the significance of the observation of steroid metabolites in triatomine feces [40], [41].…”
Section: Discussionmentioning
confidence: 99%
“…Human transmission in rural areas in endemic countries is mainly through triatomine insect bites, but in urban areas in either endemic or nonendemic countries, T. cruzi infection occurs through blood transfusions or occasionally organ transplants. 3,4 The reactivation of CD revealed as a febrile syndrome sometimes accompanied by skin manifestations, myocarditis and meningoencephalitis, has been associated with immunosuppressive states such as those induced by hematological malignancies, 5 corticosteroid therapy, 6 kidney 7 and heart transplantation 8 and AIDS. 9 In recent preliminary studies, we have described 10,11 the outcome of CD in bone marrow transplantation (BMT) patients.…”
Section: Reactivation; Immunosuppressionmentioning
confidence: 99%
“…Ainda Schenone e Rojas 28 realizando xenodiagnóstico em nove pacientes chagásicos crônicos, por um período médio de 3,3 anos verificaram que todos permaneceram na forma indeterminada apesar de terem níveis diferentes de parasitemia. Rassi et al 25 verificaram que o aumento da parasitemia em chagásicos que usaram corticóides não influenciou a clínica da enfermidade. Pereira et al 21 constataram em estudo de oito anos que a progressão da cardiopatia chagásica crônica não está associada ao xenodiagnóstico positivo embora, esses mesmos autores 22 , encontraram parasitemias mais altas em pacientes cardiopatas.…”
Section: Pacientes E Métodosunclassified