Influencing Endothelial Cells' Roles in Inflammation and Wound Healing Through Nucleic Acid Delivery

Lallo, Valerie; Bracaglia, Laura G.

doi:10.1089/ten.tea.2023.0296

Tissue Engineering Part A

2024

DOI: 10.1089/ten.tea.2023.0296

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Influencing Endothelial Cells' Roles in Inflammation and Wound Healing Through Nucleic Acid Delivery

Valerie Lallo,

Laura G. Bracaglia

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2024

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Cited by 2 publications

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Hydrogels for Nucleic Acid Drugs Delivery

Liu,

Xi,

Fan

et al. 2024

Adv Healthcare Materials

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Nucleic acid drugs are one of the hot spots in the field of biomedicine in recent years, and play a crucial role in the treatment of many diseases. However, its low stability and difficulty in target drug delivery are the bottlenecks restricting its application. Hydrogels are proven to be promising for improving the stability of nucleic acid drugs, reducing the adverse effects of rapid degradation, sudden release, and unnecessary diffusion of nucleic acid drugs. In this review, the strategies of loading nucleic acid drugs in hydrogels are summarized for various biomedical research, and classify the mechanism principles of these strategies, including electrostatic binding, hydrogen bond based binding, hydrophobic binding, covalent bond based binding and indirect binding using various carriers. In addition, this review also describes the release strategies of nucleic acid drugs, including photostimulation‐based release, enzyme‐responsive release, pH‐responsive release, and temperature‐responsive release. Finally, the applications and future research directions of hydrogels for delivering nucleic acid drugs in the field of medicine are discussed.

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Hydrogels for Nucleic Acid Drugs Delivery

Liu,

Xi,

Fan

et al. 2024

Adv Healthcare Materials

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Dynamics of Endothelial Cell Diversity and Plasticity in Health and Disease

Larionov,

Hammer,

Fiedler

et al. 2024

Cells

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Endothelial cells (ECs) are vital structural units of the cardiovascular system possessing two principal distinctive properties: heterogeneity and plasticity. Endothelial heterogeneity is defined by differences in tissue-specific endothelial phenotypes and their high predisposition to modification along the length of the vascular bed. This aspect of heterogeneity is closely associated with plasticity, the ability of ECs to adapt to environmental cues through the mobilization of genetic, molecular, and structural alterations. The specific endothelial cytoarchitectonics facilitate a quick structural cell reorganization and, furthermore, easy adaptation to the extrinsic and intrinsic environmental stimuli, known as the epigenetic landscape. ECs, as universally distributed and ubiquitous cells of the human body, play a role that extends far beyond their structural function in the cardiovascular system. They play a crucial role in terms of barrier function, cell-to-cell communication, and a myriad of physiological and pathologic processes. These include development, ontogenesis, disease initiation, and progression, as well as growth, regeneration, and repair. Despite substantial progress in the understanding of endothelial cell biology, the role of ECs in healthy conditions and pathologies remains a fascinating area of exploration. This review aims to summarize knowledge and concepts in endothelial biology. It focuses on the development and functional characteristics of endothelial cells in health and pathological conditions, with a particular emphasis on endothelial phenotypic and functional heterogeneity.

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Influencing Endothelial Cells' Roles in Inflammation and Wound Healing Through Nucleic Acid Delivery

Cited by 2 publications

References 122 publications

Hydrogels for Nucleic Acid Drugs Delivery

Hydrogels for Nucleic Acid Drugs Delivery

Dynamics of Endothelial Cell Diversity and Plasticity in Health and Disease

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