Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation

Horiike, Norio; Iuchi, Hidehito; Ninomiya, T.; Kawai, Keiko; Kumagi, Teru; Michitaka, Kojiro; Masumoto, T.; Onji, Morikazu

doi:10.3892/or.9.5.1059

Cited by 33 publications

(33 citation statements)

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“…Previous studies have reported intra-hepatic distant recurrence rates of 18.7-22.5%, 62.1-67% and 81-81.7% at 1, 3 and 5 years, respectively, after percutaneous ethanol injection therapy (PEIT) (31-33), 38 and 60% at 1 and 2 years, respectively, after RFA (34), and 18 and 52% at 1 and 2 years, respectively, after RFA or microwave coagulation therapy (35). In the present subjects, distant recurrence occurred in 8.3, 19.3 and 66.3% at 1, 3 and 5 years, respectively, after the combination of TACE and RFA; these rates were comparable to those reported previously (31)(32)(33)(34)(35). The recurrences of HCC decrease liver function and worsen prognosis.…”

Section: Discussionsupporting

confidence: 77%

Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

Beppu

Sugimoto²,

Shiraki³

et al. 2010

Int J Mol Med

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Abstract. The aim of this study was to elucidate the importance of three tumor markers, ·-fetoprotein (AFP), Lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3), and des-Á-carboxy prothrombin (DCP), for detecting and predicting the recurrence of hepatocellular carcinomas (HCCs). A total of 108 patients with initial non-advanced HCC who underwent curative radiofrequency ablation (RFA) in our hospital were enrolled in this study. The effectiveness of the three tumor markers for detecting recurrence and recurrence-free survival was analyzed. Positivity of these three makers was not markedly increased at the first or second recurrence. In addition, there was no significant correlation between the initial and recurrent levels of each tumor marker. The tumor marker that was positive at the time of initial HCC was not necessarily positive at recurrence. The tumor marker levels at recurrence were not correlated with pre-ablation levels. No significant correlation was found in the tumor marker values between pre-ablation and the time of recurrence. On multivariate analysis, high AFP-L3 levels (≥10%) were significantly predictive of recurrence-free survival. All three tumor markers should be routinely measured to detect recurrence during follow-up after RFA. Especially high AFP-L3 levels should be followed closely.

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Section: Discussionsupporting

confidence: 77%

Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

Beppu

Sugimoto²,

Shiraki³

et al. 2010

Int J Mol Med

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“…R adiofrequency (RF) ablation is used for the treatment of malignant diseases in the liver, lung, kidney, and bone (1)(2)(3)(4). The method facilitates thermal injury and thus cell death by means of coagulation necrosis to the tumor through electromagnetic energy deposition (1,2).…”

mentioning

confidence: 99%

Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, including Liver Regeneration

Rozenblum¹,

Zeira²,

Bulvik³

et al. 2015

Radiology

134

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“…Complete ablation of HCC is required for prevention of local recurrence and a good prognosis (21). For small HCC !…”

Section: Discussionmentioning

confidence: 99%

Histopathology of the Tissue Adhering to the Multiple Tine Expandable Electrodes Used for Radiofrequency Ablation of Hepatocellular Carcinoma Predicts Local Recurrence

et al. 2012

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Objective To assess the ability to predict the local recurrence of hepatocellular carcinoma by analyzing tissues adhering to the radiofrequency ablation probe after complete ablation. Methods From May 2002 to March 2011, tissue specimens adhering to the radiofrequency ablation probe from 284 radiofrequency ablation sessions performed for hepatocellular carcinomas ! 3 cm in size were analyzed. The specimens were classified as either viable tumor tissue or complete necrosis, and the local recurrence rates were calculated using the Kaplan-Meier method.Results From the tumors ! 3 cm in size, viable tissue was present in 6 (2.1%) of 284 specimens, and the local recurrence rates after 1 and 2 years of follow-up were 6.7% and 11.2%, respectively. Local recurrence developed significantly earlier in the viable tissue group. The recurrence rate was not significantly different based on whether transcatheter arterial chemoembolization was performed. Conclusion The histopathology of the tissue adhering to the radiofrequency ablation probes used for hepatocellular carcinoma treatment can predict local recurrence. Additional aggressive treatment for patients with viable tissue can therefore improve the overall survival.

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Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation

Cited by 33 publications

References 0 publications

Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation

Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, including Liver Regeneration

Histopathology of the Tissue Adhering to the Multiple Tine Expandable Electrodes Used for Radiofrequency Ablation of Hepatocellular Carcinoma Predicts Local Recurrence

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