Influencing factors of QTc among the clinical characteristics in type 2 diabetes mellitus

Subbalakshmi, N. K.; Adhikari, Prabha; Rao, Kavyarashmi; Jeganathan, P. S.

doi:10.1016/j.diabres.2010.03.001

Cited by 26 publications

(29 citation statements)

References 25 publications

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“…In the presence of diabetes, QTc abnormality was significantly increased, in line with the previous studies,[827] and this can be explained by hyperglycemia-induced alteration. Half of cases had hypertension and diabetes together with poor glycemic control as seen in our previously published study,[28] so both chronic conditions have to be tackled simultaneously.…”

Section: Discussionsupporting

confidence: 91%

QTc interval in young Gujarati hypertensives: Effect of disease, antihypertensive monotherapy, and coexisting risk factors

Solanki

Gadhavi

Makwana

et al. 2016

Journal of Pharmacology and Pharmacotherapeutics

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Objectives:To study the effect of disease duration, treatment and risk factors on QTc interval among young hypertensives.Materials and Methods:A case–control study was conducted on 142 hypertensives (60 males, 82 females) taking calcium channel blocker (CCB) or angiotensin-converting enzyme inhibitor (ACEI) as monotherapy. After blood pressure measurement, we recorded lead II electrocardiograph with minimum ten waveforms. QTc was derived from average of ten values using Bazett's formula. QTc interval >0.43 s in male and >0.45 s in female was considered abnormal.Results:Cases had mean duration of hypertension 5 years, mean age of 40 years, and poor blood pressure control (systolic blood pressure >140 and diastolic blood pressure >90 mm of Hg). Newly diagnosed hypertensives had significantly higher QTc values than the matched known cases (0.44 vs. 0.42 s, P < 0.05). Known hypertensives did not differ significantly in QTc values by the duration of disease. CCB users showed small, insignificant disadvantage for abnormally prolonged QTc values than ACEI users. With coexisting diabetes, smoking, and positive family history of hypertension, there was odds risk of 7.69, 2.75, and 2.54, respectively for prolonged QTc.Conclusion:Our study showed prolonged QTc in hypertensives more so in newly diagnosed, unaffected by duration or use of ACEI, or CCB but associated with modifiable risk factors. This underscores high risk of repolarization abnormality-induced future events, suggesting early screening of hypertension, strict blood pressure control, optimum use of QTc measurement, and preventive pharmacotherapy to reduce this aftermath.

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Section: Discussionsupporting

confidence: 91%

QTc interval in young Gujarati hypertensives: Effect of disease, antihypertensive monotherapy, and coexisting risk factors

Solanki

Gadhavi

Makwana

et al. 2016

Journal of Pharmacology and Pharmacotherapeutics

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“…Micro albuminuria is a renal marker of generalized vascular endothelial damage and early atherosclerosis [16] . Another explanation by suggested the relationship between high prevalence of diabetic cardiovascular autonomic neuropathy (CAN) in diabetic nephropathy with QT prolongation as earlier studies have suggested that QTc duration is specific and easier methods for determination of CAN [17] Also in this study prolonged QTc interval associated with higher incidence of diabetic retinopathy which in concordance with other studies in T2DM [18] while contrasted another studies [10] . but in regression analysis retinopathy was non-significant risk factor of QTc interval prolongation.…”

Section: Discussioncontrasting

confidence: 47%

Prevalence and Risk Factors of Prolonged QTc Interval among Egyptian Type 2 Diabetes Patients

Aboelnaga¹

2016

jmscr

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“…Several risk factors of prolonged QTc interval among patients with diabetes have been cited in the literature including age [17, 18], gender [19], components of insulin resistance syndrome such as BMI [20, 21], hypertension [5, 17–20, 22], insulin concentration [21, 23, 24], hyperglycemia [16, 25], diabetic microvascular complications such as diabetic retinopathy [19], neuropathy [19] and microalbuminuria, and preexisting coronary heart disease [18, 20]. Although there are inconsistencies among studies regarding all the various risk factors, hypertension was identified by most studies as an independent risk factor.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Prolonged QTc Interval among Chinese Patients with Type 2 Diabetes

Ren

Zhang

et al. 2012

Experimental Diabetes Research

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Objectives. The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes. Methods. The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. The QT interval corrected for heart rate (QTc) was calculated using Bazett's formula. Additional demographic and laboratory data were also collected. Potential risk factors of prolonged QTc interval were assessed using multivariable regression. Results. The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes was 30.1%. Height (OR 0.156, 95% CI 0.032~0.748), waist circumference (OR 1.025, 95% CI 1.010~1.040), diastolic blood pressure (OR 1.016, 95% CI 1.007~1.026), postprandial glucose (OR 1.040, 95% CI 1.022~1.059), fasting insulin (OR 1.014, 95% CI 1.003~1.025), and presence of microalbuminuria (OR 1.266, 95% CI 1.033~1.551) were significant risk factors. Conclusions. The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes is high. Risk factors for prolongation of QTc interval were low height, high waist circumference, increasing diastolic blood pressure levels, high postprandial glucose levels, high fasting insulin levels, and presence of microalbuminuria.

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Influencing factors of QTc among the clinical characteristics in type 2 diabetes mellitus

Cited by 26 publications

References 25 publications

QTc interval in young Gujarati hypertensives: Effect of disease, antihypertensive monotherapy, and coexisting risk factors

QTc interval in young Gujarati hypertensives: Effect of disease, antihypertensive monotherapy, and coexisting risk factors

Prevalence and Risk Factors of Prolonged QTc Interval among Egyptian Type 2 Diabetes Patients

Prevalence and Risk Factors of Prolonged QTc Interval among Chinese Patients with Type 2 Diabetes

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