To improve person-centered care (PCC) competence among nursing students, various associated factors must be considered. This study aimed to identify the factors influencing PCC competence among South Korean nursing students, using a descriptive, cross-sectional design. Participants were recruited from three nursing colleges in South Korea using convenience sampling. Data were collected from 1 December 2020 to 31 January 2021, using structured self-report questionnaires. Demographic information, positive psychological capital, ego-resiliency, and depression of the participants were assessed. Descriptive statistics, independent t-tests, one-way analyses of variance, and hierarchical multiple regression analysis were used in statistical analysis. Participants with highly positive psychological capital (r = 0.509, p < 0.001) and high ego-resiliency (r = 0.480, p < 0.001) had very good PCC competence. The multiple regression analysis revealed that 30.1% of the variance in PCC competence is attributable to positive psychological capital and ego-resiliency (F = 34.59, p < 0.001, adjusted R2 = 0.301). These results highlighted the need for strategies to enhance psychological factors, such as positive psychological capital and ego-resiliency, that could boost PCC competence in nursing students.