Influencing factors on the suitability of organ-cultured corneas

Gavrilov, Jean-Christophe; Borderie, Vincent; Laroche, L.; Delbosc, B.

doi:10.1038/eye.2009.312

Cited by 42 publications

(33 citation statements)

References 20 publications

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“…In parallel to Spelsberg et al 10 and Gavrilov et al, 29 we did not find an increased contamination rate for septic donors. This is in contrast to the results of other investigations.…”

Section: Discussionsupporting

confidence: 88%

Risk Factors for Donor Cornea Contamination

Linke

Fricke

Eddy

et al. 2013

Cornea

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“…In parallel to Spelsberg et al 10 and Gavrilov et al, 29 we did not find an increased contamination rate for septic donors. This is in contrast to the results of other investigations.…”

Section: Discussionsupporting

confidence: 88%

Risk Factors for Donor Cornea Contamination

Linke

Fricke

Eddy

et al. 2013

Cornea

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“…Most show an influence of donor age either on the percentage of corneas suitable for PK or on ECD. For example, Gavrilov et al 16 reported that 13% of organ-cultured corneas from donors 40 years were unsuitable for PK because of † Suture adjustment/removal, cataract surgery, refractive surgery. insufficient endothelium, and this rose to 32% for corneas from donors 80 years (cf.…”

Section: Discussionmentioning

confidence: 99%

The Suitability of Corneas Stored by Organ Culture for Penetrating Keratoplasty and Influence of Donor and Recipient Factors on 5-Year Graft Survival

Armitage

Jones

Zambrano

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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“…Utilization rates may be affected by several factors. Gavrilov and co-authors advocate an age limit of 80 or less, death to tissue retrieval time of less than 6 h and tissue retrieval to processing time of less than 24 h to minimize the percentage of discarded corneas (Gavrilov et al 2010). Linke et al cite the main factor in their comparatively low utilization rate of 43.5 % being a required minimum endothelial cell count of 2000 cells/mm 2 , higher than the requirement of most other countries (Linke et al 2013).…”

Section: Yearmentioning

confidence: 98%

Implementation of Organ Culture storage of donor corneas: a 3 year study of its impact on the corneal transplant wait list at the Lions New South Wales Eye Bank

et al. 2016

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Organ Culture corneal storage offers an extended storage time and increased donor pool and tissue assessment opportunities. In September 2011, the Lions New South Wales Eye Bank (LNSWEB) moved from hypothermic storage to Organ Culture corneal storage. This study evaluates the impact of implementation of Organ Culture on donor eye retrieval and the corneal transplant waiting list over a 3 year period in NSW, Australia. Retrospective review of the LNSWEB data from September 2011 to August 2014. Tissue collection, waiting list and tissue utilization data were recorded. The data from September 2008 to August 2011 for Optisol-GS storage was used for comparison. The annual donor and cornea collection rate increased 35 % and 44 % respectively with Organ Culture compared to Optisol-GS storage. The utilization rate of corneal tissue increased from 73.4 % with hypothermic storage to 77.2 % with Organ Culture storage. The transplant wait list decreased by 77.3 % from September 2011 to August 2014 and correlated with the increased rate of corneal transplantation (r = -0.9381, p < 0.0001). No other factors impacting the wait list changed over this period. Corneas not used from either storage method were due to unacceptable endothelial cell density/viability. The contamination rate of corneas stored in Organ Culture medium was low at 1.74 %. The Organ Culture storage method increases the corneal donor pool available to Eye banks. The practical benefits of the extended storage time and increased donor assessment opportunities have directly led to an increase in corneal utilization rate and a significant decrease in recipient wait list time.

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Influencing factors on the suitability of organ-cultured corneas

Cited by 42 publications

References 20 publications

Risk Factors for Donor Cornea Contamination

Risk Factors for Donor Cornea Contamination

The Suitability of Corneas Stored by Organ Culture for Penetrating Keratoplasty and Influence of Donor and Recipient Factors on 5-Year Graft Survival

Implementation of Organ Culture storage of donor corneas: a 3 year study of its impact on the corneal transplant wait list at the Lions New South Wales Eye Bank

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