Influenza A and B outbreaks differed in their associations with climate conditions in Shenzhen, China

Ma, Pan; Tang, Xiaoxin; Zhang, Li; Wang, Xinzi; Wang, Weimin; Wang, Shigong; Zhou, Ning

doi:10.1007/s00484-021-02204-y

Cited by 22 publications

(19 citation statements)

References 56 publications

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“…The potential explanation was that the latitudes and climate characteristics might have an impact on the transmission of Flu-B. (13) Cold weather was associated with higher cumulative risks of in uenza activity in our study which was consistent with previous studies performed in temperate and subtropical areas. (5,8,25) Low temperature was proved to keep the stability of the in uenza virus particle by promoting the ordering of lipids on the viral membrane, which was critical for airborne transmission.…”

Section: Discussionsupporting

confidence: 92%

“…The prevalence pattern of Flu-A in Macau was very similar to that of Flu-A in other subtropical cities in China. (13,24,25) Flu-B had a peak in winter in Shanghai, which is a subtropical city at mid-latitudes in China, while the peak was found in spring in Macau. (25) Macau is at low latitudes in China and has shorter winter.…”

Section: Discussionmentioning

confidence: 99%

“…Rainfall was a signi cant meteorological factor positive associated with in uenza activity in Hong Kong, but the association were not found in Guangzhou nor Shenzhen. (11)(12)(13) A moderate wind (2-3m/s) was considered as a risk factor for in uenza activity in Shenzhen but no association was shown in Guangzhou. (12,13) In addition, meteorological factors might have different effects on different in uenza types, but the research was limited.…”

Section: Introductionmentioning

confidence: 99%

“…(11)(12)(13) A moderate wind (2-3m/s) was considered as a risk factor for in uenza activity in Shenzhen but no association was shown in Guangzhou. (12,13) In addition, meteorological factors might have different effects on different in uenza types, but the research was limited. A study of 8 temperate regions, 2 subtropical regions and one tropical region showed a U-shaped association between temperature and Flu-A, but not Flu-B.…”

Section: Introductionmentioning

confidence: 99%

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The association between multiple meteorological factors and seasonal influenza A and B virus transmission in Macau

Zhang

et al. 2022

Preprint

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Background and objectives: Few studies evaluated the influence of meteorological factors on different influenza types activity in subtropical regions. The study aimed to explore the association between meteorological factors and the onset of influenza A (Flu-A) and B (Flu-B) in Macau.Methods: Daily influenza cases data were collected from Kiang Wu Hospital from January 1st, 2014 to December 31st, 2018 in Macau. Daily meteorological data were obtained from Macau Meteorological Service. The distributed lag non-linear model (DLNM) was used to estimate the effects of meteorological factors on the seasonal influenza outbreak.Results：Mean temperature had the peaking risks of both types at 4.0°C and 28.0°C. For the diurnal temperature range (DTR), the peaks of the cumulative relative risk (RR) of Flu-A were at 1.0°C and 5.0°C, while the cumulative RR of Flu-B increased as the DTR decreased. The association between influenza and relative humidity were showed a U-shape curve. The risk of influenza increased when the relative humidity was below 50% or above 90%. Both types increased significantly when the sunshine duration was below about 3.5 hours. Taking the median value as the reference, a significant cold effect was observed along 16-24 lag days in Flu-A. The lag effects were found in low-DTR, humid and short sunshine conditions in both types.Conclusions：This study revealed the complex non-linear association between meteorological factors and the different influenza types activity in Macau. The finding helped to develop an early warning system to improve the response capacity to influenza epidemics.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between multiple meteorological factors and seasonal influenza A and B virus transmission in Macau

Zhang

et al. 2022

Preprint

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“…Differences in seasonal changes in precipitation and humidity as well as seasonal changes in behaviors such as social mixing may relate to the differences in distinctness of influenza seasons. Despite ample literature showing statistical associations between influenza (or other respiratory viruses) and seasonal covariates, notably temperature, precipitation, humidity, and wind speed (35,(43)(44)(45)(46)(47), there is a dearth of research seeking to assess quantitative support for the existence of seasonal or annual patterns in the tropics (48).…”

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

Repeatability and timing of tropical influenza epidemics

Servadio

Thái

Choisy

et al. 2022

Preprint

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Much of the world experiences influenza in yearly recurring seasons, particularly in temperate areas. These patterns can be considered repeatable, occurring predictably and consistently. In tropical areas, including southeast Asia, this consistency is less conspicuous. This study aimed to assess repeatability of influenza in Vietnam. A mathematical model was developed incorporating periods of increased transmission, and fit to data from sentinel hospitals throughout Vietnam as well as four temperate locations. Repeatability was evaluated through the variance of the timings of peak transmission. Model fits from Vietnam show high variance (sd = 70-171) in peak transmission timing; peaks occurred at irregular intervals and throughout different times of year. Fits from temperate locations showed regular, annual epidemics in winter months, with low variance in peak timings (sd = 33-74). This suggests that influenza patterns are not repeatable or seasonal in Vietnam. Influenza prevention in Vietnam therefore cannot rely anticipating regularly occurring outbreaks.

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Temporal Association Among Influenza-Like Illness, Cardiovascular Events, and Vaccine Dose in Patients With High-Risk Cardiovascular Disease

Hegde,

Claggett,

Udell

et al. 2023

JAMA Netw Open

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ImportanceInfluenza-like illness (ILI) activity has been associated with increased risk of cardiopulmonary (CP) events during the influenza season. High-dose trivalent influenza vaccine was not superior to standard-dose quadrivalent vaccine for reducing these events in patients with high-risk cardiovascular (CV) disease in the Influenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure (INVESTED) trial.ObjectiveTo evaluate whether high-dose trivalent influenza vaccination is associated with benefit over standard-dose quadrivalent vaccination in reducing CP events during periods of high, local influenza activity.Design, Setting, and ParticipantsThis study was a prespecified secondary analysis of INVESTED, a multicenter, double-blind, active comparator randomized clinical trial conducted over 3 consecutive influenza seasons from September 2016 to July 2019. Follow-up was completed in July 2019, and data were analyzed from September 21, 2016, to July 31, 2019. Weekly Centers for Disease Control and Prevention (CDC)–reported, state-level ILI activity was ascertained to assess the weekly odds of the primary outcome. The study population included 3094 patients with high-risk CV disease from participating centers in the US.InterventionParticipants were randomized to high-dose trivalent or standard-dose quadrivalent influenza vaccine and revaccinated for up to 3 seasons.Main Outcomes and MeasuresThe primary outcome was the time to composite of all-cause death or CP hospitalization within each season. Additional measures included weekly CDC-reported ILI activity data by state.ResultsAmong 3094 participants (mean [SD] age, 65 [12] years; 2309 male [75%]), we analyzed 129 285 person-weeks of enrollment, including 1396 composite primary outcome events (1278 CP hospitalization, 118 deaths). A 1% ILI increase in the prior week was associated with an increased risk in the primary outcome (odds ratio [OR], 1.14; 95% CI, 1.07-1.21; P &lt; .001), CP hospitalization (OR, 1.13; 95% CI, 1.06-1.21; P &lt; .001), and CV hospitalization (OR, 1.12; 95% CI, 1.04-1.19; P = .001), after adjusting for state, demographic characteristics, enrollment strata, and CV risk factors. Increased ILI activity was not associated with all-cause death (OR, 1.00; 95% CI, 0.88-1.13; P &gt; .99). High-dose compared with standard-dose vaccine did not significantly reduce the primary outcome, even when the analysis was restricted to weeks of high ILI activity (OR, 0.88; 95% CI, 0.65-1.20; P = .43). Traditionally warmer months in the US were associated with lower CV risk independent of local ILI activity.Conclusions and RelevanceIn this secondary analysis of a randomized clinical trial, ILI activity was temporally associated with increased CP events in patients with high-risk CV disease, and a higher influenza vaccine dose did not significantly reduce temporal CV risk. Other seasonal factors may play a role in the coincident high rates of ILI and CV events.Trial RegistrationClinicalTrials.gov Identifier: NCT02787044

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Influenza A and B outbreaks differed in their associations with climate conditions in Shenzhen, China

Cited by 22 publications

References 56 publications

The association between multiple meteorological factors and seasonal influenza A and B virus transmission in Macau

The association between multiple meteorological factors and seasonal influenza A and B virus transmission in Macau

Repeatability and timing of tropical influenza epidemics

Temporal Association Among Influenza-Like Illness, Cardiovascular Events, and Vaccine Dose in Patients With High-Risk Cardiovascular Disease

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